Engineering aqueous fiber assembly into silk-elastin-like protein polymers.
Engineering aqueous fiber assembly into silk-elastin-like protein polymers.
复制标题
将水性纤维组装成丝弹性蛋白样蛋白质聚合物。
DOI：
10.1002/marc.201400058
复制
发表时间：
2014
影响因子：
4.6
通讯作者：
Wu,Xiaoyi
中科院分区：
文献类型：
--
作者：
Zeng,Like;Jiang,Linan;Teng,Weibing;Cappello,Joseph;Zohar,Yitshak;Wu,Xiaoyi
自组装肽/蛋白质纳米纤维是有价值的一维构建块，可用于创建具有设计特性和功能的复杂结构。据报道，丝弹性蛋白样蛋白质聚合物在水溶液中自组装成纳米纤维或球状聚集体可以通过调节蛋白质溶液的温度、丝块的大小和弹性蛋白块的电荷来调节。提出了用于纳米纤维形成的核-鞘模型，其中丝块位于芯中，水合弹性蛋白块位于鞘中。丝块折叠成稳定的核心（受丝块尺寸和弹性蛋白块电荷的影响）在丝弹性蛋白纳米纤维的组装中起着关键作用。此外，高温下弹性蛋白块之间增强的疏水相互作用极大地影响了丝弹性蛋白纳米纤维的纳米级特征。
Self‐assembled peptide/protein nanofibers are valuable 1D building blocks for creating complex structures with designed properties and functions. It is reported that the self‐assembly of silk‐elastin‐like protein polymers into nanofibers or globular aggregates in aqueous solutions can be modulated by tuning the temperature of the protein solutions, the size of the silk blocks, and the charge of the elastin blocks. A core‐sheath model is proposed for nanofiber formation, with the silk blocks in the cores and the hydrated elastin blocks in the sheaths. The folding of the silk blocks into stable cores—affected by the size of the silk blocks and the charge of the elastin blocks—plays a critical role in the assembly of silk‐elastin nanofibers. Furthermore, enhanced hydrophobic interactions between the elastin blocks at elevated temperatures greatly influence the nanoscale features of silk‐elastin nanofibers.