Increasing the validity of experimental models for depression
Increasing the validity of experimental models for depression
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DOI：
10.1111/j.1749-6632.2012.06669.x
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Covington, Herbert E., III
中科院分区：
文献类型：
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作者：
Dzirasa, Kafui;Covington, Herbert E., III
重性抑郁症（MDD）是一种中枢神经系统疾病，其特征是严重的情绪和情感调节障碍。动物模型作为一个强大的工具，调查这种疾病的神经生物学机制，然而，几乎没有标准化存在于广泛的可用的建模方法，最常用的。这篇综述将说明一些最具挑战性的障碍所面临的研究人员试图关联抑郁样行为的啮齿动物的症状表示在MDD。此外，一个新的系列的抑郁样标准的基础上相关的行为内表型，新的体内神经生理学测量，和多个大脑内的分子/细胞分析提出了一个潜在的解决方案，以克服这一障碍。最终，将神经生理学和细胞/生化作用联系起来，有助于表达定义的MDD样综合征，将大大扩展MDD最有效动物模型的转化价值。
Major depressive disorder (MDD) is a central nervous system disorder characterized by the culmination of profound disturbances in mood and affective regulation. Animal models serve as a powerful tool for investigating the neurobiological mechanisms underlying this disorder; however, little standardization exists across the wide range of available modeling approaches most often employed. This review will illustrate some of the most challenging obstacles faced by investigators attempting to associate depressive-like behaviors in rodents with symptoms expressed in MDD. Furthermore, a novel series of depressive-like criteria based on correlating behavioral endophenotypes, novel in vivo neurophysiological measurements, and molecular/cellular analyses within multiple brain are proposed as a potential solution to overcoming this barrier. Ultimately, linking the neurophysiological and cellular/biochemical actions that contribute to the expression of a defined MDD-like syndrome will dramatically extend the translational value of the most valid animal models of MDD.