Norbisabolane and eremophilane sesquiterpenoids from cultures of the Basidiomycete Polyporus ellisii
Norbisabolane and eremophilane sesquiterpenoids from cultures of the Basidiomycete Polyporus ellisii
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来自担子菌埃利氏猪苓培养物的降没药烷和埃里莫菲烷倍半萜类化合物
DOI：
10.1016/j.fitote.2013.08.023
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发表时间：
2013-12-01
期刊：
影响因子：
3.4
通讯作者：
Feng, Tao
中科院分区：
文献类型：
--
作者：
Wang, Shuang;Li, Zheng-Hui;Feng, Tao
从担子菌 Polyporus ellisii 培养物中分离出三种新的 11,12,15-降没药烷倍半萜类化合物 polisins A-C (1-3) 和四种新的 eremophilane 倍半萜类化合物，polylisins A-D (4-7)。这些新结构是基于广泛的光谱研究而阐明的，并且 polisin A (1) 和 Polylisin A (4) 的结构通过单晶 X 射线晶体学分析得到了证实。所有化合物均针对 11 β-羟基类固醇脱氢酶（11 β-HSD1 和 11 β-HSD2）的两种同工酶的抑制活性进行了评估。 (C) 2013 Elsevier B.V. 保留所有权利。
Three new 11,12,15-norbisabolane sesquiterpenoids, polisins A-C (1-3), and four new eremophilane sesquiterpenoids, polylisins A-D (4-7), were isolated from cultures of the Basidiomycete Polyporus ellisii. These new structures were elucidated based on extensive spectroscopic studies and the structures of polisin A (1) and polylisin A (4) were confirmed by single-crystal X-ray crystallographic analysis. All compounds were evaluated for their inhibitory activities against two isozymes of 11 beta-hydroxysteroid dehydrogenases (11 beta-HSD1 and 11 beta-HSD2). (C) 2013 Elsevier B.V. All rights reserved.