Behavior of melanocytes and keratinocytes in reticulate acropigmentation of Kitamura
Behavior of melanocytes and keratinocytes in reticulate acropigmentation of Kitamura
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DOI：
10.1111/pcmr.12453
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发表时间：
2016-03
影响因子：
4.3
通讯作者：
K. Okamura;Y. Abe;Y. Araki;Y. Hozumi;M. Kawaguchi;Tamio Suzuki
中科院分区：
文献类型：
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作者：
K. Okamura;Y. Abe;Y. Araki;Y. Hozumi;M. Kawaguchi;Tamio Suzuki
本文讨论了RAK家族中一种新的ADAM10突变的病例，并对从遗传学鉴定的患者中获得的样本进行了电子显微镜研究。一位54岁的日本女性，自青春期以来，因肢端色素沉着过度而就诊。电子显微镜显示，在茶色素沉着斑区域的角质形成细胞（K）的细胞质中，黑素体数量增加，形成黑素体复合物。
The article discusses the case of a novel ADAM10 mutation in a RAK family and presents an electron microscopic study of samples obtained from a genetically identified patient. A 54-year old Japanese woman was presented for hyperpigmentation on acral areas since puberty. Electron microscopy revealed an increased number of melanosomes in the cytoplasm of keratinocytes (K) in the area of thea hyperpigmented macules which formed melanosome complexes.