Susceptibility of human oral anaerobic bacteria to antibiotics suitable for topical use.
Susceptibility of human oral anaerobic bacteria to antibiotics suitable for topical use.
复制标题
人类口腔厌氧菌对适合局部使用的抗生素的敏感性。
DOI：
10.1111/j.1600-051x.1985.tb00917.x
复制
发表时间：
1985
影响因子：
6.7
通讯作者：
Genco,RJ
中科院分区：
文献类型：
--
作者：
Baker,PJ;Evans,RT;Slots,J;Genco,RJ
对17种具有局部使用潜力的抗生素进行了对人类口腔菌群的活性测试。给出了抑菌所需浓度（μol/1），并比较了抑菌活性。口腔可培养菌群对四环素、二甲胺四环素、多西环素、土霉素等四环素类药物和红霉素敏感。另一方面，放线菌素、卡那霉素、新霉素、链霉素、螺旋霉素、tythricin、万古霉素、克林霉素和氯霉素在高浓度下对大多数人口腔厌氧菌均无效。青霉素在高浓度时有效，但不推荐使用，因为不受低浓度抑制的微生物是青霉素酶的产生者。卡比西林对除放线菌外的所有微生物均有效。与成人牙周炎相关的革兰氏阴性菌对四环素、酪氨酸、卡比西林和克林霉素最敏感，而与局限性青少年牙周炎相关的革兰氏阴性菌对四环素或红霉素最敏感。这些数据与先前的研究结果相结合表明，一些太昔林在治疗或预防口腔疾病方面表现出良好的选择。
17 antibiotics, with potential for topical use, were tested for their activity against the human oral flora. Concentrations (μol/1) required to inhibit 90% of test strains are presented and drug activities are compared. The total cultivable oral flora was susceptible to the tetracyclines including tetracycline itself, minocyline, doxycyline, and oxytetracycline and to erythromycin. On the other hand, actinobolin, kanamycin, neomycin, streptomycin, spiramycin, tythricin, vancomycin, clindamycin, and chloramphenicol were ineffective against may of the human oral anaerobic bacteria even at high concentration. Penicillin was effective at high concentrations but could not be recommended because organisms which are not inhibited by low concentrations are penicillinase producers. Carbenicillin was effective against all organisms exceptActinobacillus actinomycetemcomitans.The gram‐negative organisms involved in adult periodontitis were most susceptible to the tetracylines, tyrothricin, carbenicillin and clindamycin, while those associated with localized juvenile periodontitis were susceptible to the tetracylines or erythromycin. These data, combined with the previous findings that some teracylines exhibit marked to good choices in the treatment or prevention of oral diseases.