Studies on vascular permeability changed in experimental brain concussion. II. Duration of altered permeability.
Studies on vascular permeability changed in experimental brain concussion. II. Duration of altered permeability.
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实验性脑震荡中血管通透性变化的研究。
DOI：
10.1007/bf00692306
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发表时间：
1968
影响因子：
12.7
通讯作者：
Y. Olsson
中科院分区：
文献类型：
--
作者：
L. Rinder;Y. Olsson
在家兔中，通过诱导短暂的颅内压脉冲产生实验性脑震荡体征，在大脑突然负荷后两天的不同时间间隔内血管内注射荧光渗透性指示剂后，观察到脑干外侧部和不同部位的荧光指示剂明显外渗，部分上颈髓后立即诱导一个震荡反应。诱导颅内压脉冲后一小时，血管渗透性就基本恢复正常，12-18小时后，血管外未观察到荧光指示剂。因此，这种类型的实验性脑震荡中血管渗透性的最初增加只是短暂的。这可能是相对于先前观察结果的重要因素，即外渗指示剂在脑干和颈髓中基本上不迁移。
The duration of increase of cerebrospinal vascular permeability in rabbits, in which signs of experimental brain concussion were produced by induction of a brief intracranial pressure pulse, was studied after intravascular injection of a fluorescent permeability indicator at various intervals of up to two days after the sudden loading of the brain.A marked extravasation of the fluorescent indicator was observed within lateral parts of the brain stem and various parts of the upper cervical cord immediately after the induction of a concussive reaction. Vascular permeability was practicaly normal again as soon as one hour after the induction of the intracranial pressure pulse and 12–18 hours later no fluorescent indicator was observed extravascularly.The initial increase of vascular permeability in this type of experimental brain concussion is thus of only short duration. This may be a factor of importance with respect to previous observations, that the extravasated indicator does not migrate substantially in the brain stem and cervical cord.