Assessment of risk of insect-resistant transgenic crops to nontarget arthropods
Assessment of risk of insect-resistant transgenic crops to nontarget arthropods
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DOI：
10.1038/nbt1381
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发表时间：
2008-02-01
影响因子：
46.9
通讯作者：
Wolt, Jeffrey D.
中科院分区：
文献类型：
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作者：
Romeis, Joerg;Bartsch, Detlef;Wolt, Jeffrey D.
一项国际倡议正在开发一种科学严谨的方法，以评估抗虫转基因作物对非目标节肢动物（NTA）造成的潜在风险。它采用了国际上在监管毒理学和环境科学中使用的风险评估分层方法。该方法的重点是制定和测试明确陈述的风险假设，最大限度地利用现有数据，并使用正式的决策准则，以测试阶段（或层次）之间的进展。该指南旨在为目前正在为IRGM作物制定自己的NTA风险评估指南的监管机构提供指导，并帮助协调世界不同国家和不同地区之间的监管要求。
An international initiative is developing a scientifically rigorous approach to evaluate the potential risks to nontarget arthropods (NTAs) posed by insect-resistant, genetically modified (IRGM) crops. It adapts the tiered approach to risk assessment that is used internationally within regulatory toxicology and environmental sciences. The approach focuses on the formulation and testing of clearly stated risk hypotheses, making maximum use of available data and using formal decision guidelines to progress between testing stages (or tiers). It is intended to provide guidance to regulatory agencies that are currently developing their own NTA risk assessment guidelines for IRGM crops and to help harmonize regulatory requirements between different countries and different regions of the world.