Synthesis, characterization, spectral, thermal analysis and biological activity studies of metronidazole complexes
Synthesis, characterization, spectral, thermal analysis and biological activity studies of metronidazole complexes
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DOI：
10.1016/j.molstruc.2018.08.095
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发表时间：
2019-01-01
影响因子：
3.8
通讯作者：
Ibrahim, Riham S.
中科院分区：
文献类型：
--
作者：
Ali, Alaa E.;Elasala, Gehan S.;Ibrahim, Riham S.
合成了甲硝唑金属配合物，并通过元素分析、红外光谱、电子光谱、磁化率和ESR谱对Cu（II）和Co（II）配合物进行了表征，以了解其几何构型和成键方式。以化学计量法，1：1，1：2，1：3（M：L）。锰、铁、钴、镍、铜、汞和镉配合物均为八面体构型，锌配合物为四面体构型。一些理论。研究了它们的电荷、键长、键角和二面角。研究了配合物的热性质。由TGA和DTA曲线估算了反应的动力学热力学参数。的配合物的热分解结束与金属氧化物的形成作为最终产物，除了在汞络合物的情况下。甲硝唑复合物对某些菌株的活性高于甲硝唑。(C)2018爱思唯尔B.V.保留所有权利。
Metronidazole metal complexes were synthesized and characterized by elemental analysis, IR, electronic spectra, magnetic susceptibility and ESR spectra of Cu (II)and Co (II) complexes to know their geometries and mode of bonding. with stochiometries, 1:1, 1:2, 1:3 (M: L). All the manganese, iron, cobalt, nickel, copper, mercury and cadmium complexes were proposed to be with octahedral geometry, while zinc complex is with tetrahedral geometry. Some theoretical. Studies were carried out to obtain the charges, bond lengths, bond angles and dihedral angles. The thermal properties of the complexes were examined. The kinetic thermodynamic parameters were estimated from the TGA and DTA curves. The thermal decomposition of the complexes ended with the formation of metal oxide as a final product except in case of Hg complex. Metronidazole complexes show higher activity than metronidazole for some strains. (C) 2018 Elsevier B.V. All rights reserved.