Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCl4-induced liver damage
Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCl4-induced liver damage
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DOI：
10.1016/j.bbrc.2005.02.076
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发表时间：
2005-04-15
影响因子：
3.1
通讯作者：
Wang, MH
中科院分区：
文献类型：
--
作者：
Jin, YS;Sa, JH;Wang, MH
研究了桑树的抗氧化活性和保肝作用。家蚕水提物具有较强的清除超氧阴离子自由基的能力。与标准制剂相比，100 mg/kg的水提物具有显著的保护肝脏的活性。组织学观察证实了上述生化结果，表明家蚕提取物与CCl4处理联合使用可减少气球退化。水提物对CCl4诱导的大鼠肝损伤有恢复作用，对FeCl2-抗坏血酸诱导的大鼠脂质过氧化反应具有抗氧化作用。根据这些结果，我们认为家蚕提取物的保肝作用与其抗氧化活性有关。(C)2005 Elsevier Inc.保留所有权利。
The antioxidant activity and liver protective effect of Morus bombycis Koidzumi were investigated. Aqueous extracts of M. bombycis Koidzumi had higher superoxide radical scavenging activity than other types of extracts. The aqueous extract at a dose of 100 mg/kg showed significant hepato protective activity when compared with that of a standard agent. The biochemical results were confirmed by histological observations indicating that M. bombycis Koidzumi extract together with CCl4 treatment decreased ballooning degeneration. The water extract recovered the CCl4-induced liver injury and showed antioxidant effects in assays of FeCl2-ascorbic acid-induced lipid peroxidation in rats. Based on these results, we Suggest that the hepatoprotective effect of the M. bombycis Koidzumi extract is related to its antioxidative activity. (c) 2005 Elsevier Inc. All rights reserved.