An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals
An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals
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DOI：
10.1038/ejcn.2009.20
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发表时间：
2009-08-01
影响因子：
4.7
通讯作者：
Garg, M. L.
中科院分区：
文献类型：
--
作者：
Micallef, M. A.;Munro, I. A.;Garg, M. L.
高敏C反应蛋白（hs-CRP）是低度持续性炎症的标志物。Omega-3（n-3）脂肪酸具有抗炎特性，并与降低心血管疾病（CVD）风险有关。本研究的目的是探讨血浆n-3脂肪酸浓度是否与hs-CRP浓度相关。共124名自由生活的成年人，分为血浆hs-CRP（3.0 mg/l）的三分位数。身体成分和人体测量记录。使用免疫测定法分析超敏C反应蛋白，并通过气相色谱法测量脂肪酸。血浆hs-CRP浓度与总n-3脂肪酸（P=0.05）、二十碳五烯酸（EPA; P=0.002）和二十二碳五烯酸（DPA; P=0.01）呈负相关。与其他三分位数相比，最高hs-CRP三分位数（>3.0 mg/l）的总n-3脂肪酸、EPA和DPA浓度显著降低（P
High sensitivity C-reactive protein (hs-CRP) is a marker of low-grade sustained inflammation. Omega-3 (n-3) fatty acids have anti-inflammatory properties and are associated with reduced cardiovascular disease (CVD) risk. The aim of this study was to investigate whether plasma n-3 fatty acid concentration is related to hs-CRP concentration. A total of 124 free-living adults, were divided into tertiles of plasma hs-CRP (3.0 mg/l). Body composition and anthropometric measurements were recorded. Hs-CRP was analysed using immunoassays and fatty acids were measured by gas chromatography. Plasma hs-CRP concentration was negatively correlated with total n-3 fatty acids (P=0.05), eicosapentaenoic acid (EPA; P=0.002) and docosapentaenoic acid (DPA; P=0.01). The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P