A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease.
A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease.
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DOI：
10.1177/1179546820977196
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Deshmukh A
中科院分区：
文献类型：
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作者：
Thakkar S;Arora S;Kumar A;Jaswaney R;Faisaluddin M;Ammad Ud Din M;Shariff M;Barssoum K;Patel HP;Nirav A;Jani C;Patel K;Savani S;DeSimone C;Mulpuru S;Deshmukh A
2019年冠状病毒病（COVID-19）的影响深远。尽管COVID-19主要影响呼吸系统，但它也与多种心血管（CV）表现相关，预示着预后极差。心血管疾病的主要假设是通过直接的心肌感染和全身炎症。我们对现有文献进行了系统综述，为了解COVID-19的CV表现和结局提供基础。PubMed和EMBASE数据库从数据库建立到2020年4月27日进行了电子检索。进行了第二次文献综述，纳入了在最初检索之后但在提交之前发表的主要试验和指南。纳入标准包括病例报告、病例系列和报告COVID-19感染患者CV结局的观察性研究。本文回顾了当前的COVID-19疾病和CV结局文献，揭示了大量具有潜在治疗和预防途径的CV表现。未来的研究需要在更机械的水平上了解COVID-19对心肌的影响，从而为提高死亡率和发病率提供途径。
The impact of coronavirus disease, 2019 (COVID-19), has been profound. Though COVID-19 primarily affects the respiratory system, it has also been associated with a wide range of cardiovascular (CV) manifestations portending extremely poor prognosis. The principal hypothesis for CV involvement is through direct myocardial infection and systemic inflammation. We conducted a systematic review of the current literature to provide a foundation for understanding the CV manifestations and outcomes of COVID-19. PubMed and EMBASE databases were electronically searched from the inception of the databases through 27 April 2020. A second literature review was conducted to include major trials and guidelines that were published after the initial search but before submission. The inclusion criteria for studies to be eligible were case reports, case series, and observation studies reporting CV outcomes among patients with COVID-19 infection. This review of the current COVID-19 disease and CV outcomes literature revealed a myriad of CV manifestations with potential avenues for treatment and prevention. Future studies are required to understand on a more mechanistic level the effect of COVID-19 on the myocardium and thus provide avenues to improve mortality and morbidity.