The structure of lifetime manic-hypomanic spectrum
The structure of lifetime manic-hypomanic spectrum
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DOI：
10.1016/j.jad.2008.04.019
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发表时间：
2009-01-01
影响因子：
6.6
通讯作者：
Fagiolini, A.
中科院分区：
文献类型：
--
作者：
Cassano, G. B.;Mula, M.;Fagiolini, A.
背景：观察到双相情感障碍经常被忽视，这促使了筛查仪器的发展，旨在提高临床和非临床样本中双相情感的识别。从终生方法开始，光谱项目的研究人员开发了情绪光谱自我报告(MOODS-SR)，评估单相和双相情绪精神病理的阈值水平表现，以及非典型症状、行为特征和气质特征。本研究的目的是使用Mods-SR的68个条目来检验躁狂/低躁狂症的结构，该量表探索与躁狂/低躁狂症相关的认知、情绪和能量/活动特征。方法：使用在意大利匹兹堡和比萨招募的617名双相情感障碍患者的数据库。结果：初步确定了9个因素，分别为精神运动激活性、创造性、混合性不稳定、社交/外向性、精神性/神秘性/精神病性、混合性易怒、自尊膨胀、欣快感、浪费/鲁莽，共可解释项目变异的56.4%。在随后的基于IRT的双因素分析中，只保留了其中的五个因素(精神运动激活、混合不稳定、灵性/神秘主义/精神质、混合易怒、欣快感)。结论：我们的数据证实了精神运动激活在躁狂/轻躁狂中的中心作用，并支持单纯躁狂(精神运动激活和欣快感)和混合性躁狂(混合不稳定和混合易怒)的定义，从而有机会识别具有特定特征的患者，以便更好地临床和神经生物学定义。(C)2008年，爱思唯尔出版。
Background: The observation that bipolar disorders frequently go unrecognized has prompted the development of screening instruments designed to improve the identification of bipolarity in clinical and non-clinical samples. Starting from a lifetime approach, researchers of the Spectrum Project developed the Mood Spectrum Self-Report (MOODS-SR) that assesses threshold-level manifestations of unipolar and bipolar mood psychopathology, but also atypical symptoms, behavioral traits and temperamental features. The aim of file present study is to examine the structure of mania/hypomania using 68 items of the MOODS-SR that explore cognitive, mood and energy/activity features associated with mania/hypomania.Methods: A data pool of 617 patients with bipolar disorders, recruited at Pittsburgh and Pisa, Italy was used for this Purpose. Classical exploratory factor analysis, based on a tetrachoric matrix, was carried Out oil the 68 items, followed by all Item Response Theory (FRT)-based factor analytic approach.Results: Nine factors were initially identified, that include Psychomotor Activation, Creativity, Mixed Instability, Sociability/Extraversion, Spirituality/Mysticium/Psychoticism, Mixed Irritability, Inflated Self-esteem, Euphoria, Wastefulness/Recklessness, and account overall for 56.4% of the variance of items. In a subsequent IRT-based bi-factor analysis, only five of them (Psychomotor Activation, Mixed Instability, Spirituality/Mysticism/Psychoticism, Mixed Irritability, Euphoria) were retained.Conclusions: Our data confirm the central role of Psychomotor Activation in mania/hypomania and Support the definitions of pure manic (Psychomotor Activation and Euphoria) and mixed manic (Mixed Instability and Mixed Irritability) components, bearing the opportunity to identify patients with specific profiles for a better clinical and neurobiological definition. (c) 2008 Published by Elsevier B.V.