Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
复制标题
益生菌对抑郁症的影响：随机对照试验的系统回顾和荟萃分析
作者：
Huang R;Wang K;Hu J
据报道，肠道益生菌在肠道和大脑之间的双向交流中发挥着重要作用。益生菌对抑郁症患者可能是必不可少的，抑郁症仍然是一个全球健康挑战，因为抑郁症是一种代谢性大脑疾病。然而，益生菌对抑郁症的疗效存在争议。本研究旨在系统综述基于益生菌的干预对抑郁症影响的现有证据。通过筛选多个数据库和灰色文献确定的随机对照试验被纳入荟萃分析。Meta分析是使用Review Manager 5.3软件使用固定效应模型进行的。Meta分析显示，益生菌显著降低受试者的抑郁量表评分(MD=-0.30，95%CI(-0.51~-0.09)，p=0.005)。益生菌对健康人群(MD=-0.25，95%CI(-0.47~-0.03)，p=0.03)和重度抑郁症(MDD)患者(MD=-0.73，95%CI(-1.37~-0.09)，p=0.03)均有影响。益生菌对60岁以下人群有影响(MD=-0.43，95%CI(-0.72~-0.13)，p=0.005)，对65岁以上人群无影响(MD=-0.18，95%CI(-0.47~0.11)，p=0.22)。这是第一次系统的综述和荟萃分析，目的是确定益生菌对抑郁症的影响。我们发现，益生菌与抑郁症的显著减少有关，强调了对这一潜在的抑郁症预防策略进行进一步研究的必要性。
It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotics for depression is controversial. This study aimed to systematically review the existing evidence on the effect of probiotics-based interventions on depression. Randomized, controlled trials, identified through screening multiple databases and grey literature, were included in the meta-analysis. The meta-analysis was performed using Review Manager 5.3 software using a fixed-effects model. The meta-analysis showed that probiotics significantly decreased the depression scale score (MD (depressive disorder) = -0.30, 95% CI (-0.51--0.09), p = 0.005) in the subjects. Probiotics had an effect on both the healthy population (MD = -0.25, 95% CI (-0.47--0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = -0.73, 95% CI (-1.37--0.09), p = 0.03). Probiotics had an effect on the population aged under 60 (MD = -0.43, 95% CI (-0.72--0.13), p = 0.005), while it had no effect on people aged over 65 (MD = -0.18, 95% CI (-0.47-0.11), p = 0.22). This is the first systematic review and meta-analysis with the goal of determining the effect of probiotics on depression. We found that probiotics were associated with a significant reduction in depression, underscoring the need for additional research on this potential preventive strategy for depression.