Kinetics of dehydration and isomerization of prostaglandins E 1 and E 2 .
Kinetics of dehydration and isomerization of prostaglandins E 1 and E 2 .
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前列腺素E 1 和E 2 脱水和异构化的动力学。
DOI：
10.1002/jps.2600620406
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发表时间：
1973
影响因子：
3.8
通讯作者：
A. Aguiar
中科院分区：
文献类型：
--
作者：
D. Monkhouse;L. Van Campen;A. Aguiar
在 60°、pH 范围 1-10 下研究了前列腺素 E1 和 E2 的降解。对于脱水和重排反应，连续的一级反应似乎在 pH 4 以上时起作用。 pH 值低于 3 时，脱水似乎与氢离子浓度有关。在相同条件下，pH 值范围为 4-10 时，E2 的脱水速度比 E1 快两到三倍。在 pH 10 时，E1 和 E2 的重排速率大致相同。随着 pH 值的降低，E2 重排速率逐渐超过 E1，以致在 pH 6 时，E2 重排速率是 E1 的 15 倍。这些数据表明，顺式-Δ5双键积极参与E2的重排反应，并且与E1相比，导致该分子具有更高的反应性。
The degradation of prostaglandins E1 and E2 was studied at 60° at a pH range of 1–10. A consecutive first-order reaction appeared to be operative above pH 4 for the dehydration and rearrangement reactions. Below pH 3 the dehydration appeared to be first order with respect to hydrogen-ion concentration. The rate of dehydration of E2 was two to three times faster than that of E1 under the same conditions over a pH range of 4–10. The rearrangement of E1 and E2 proceeded at approximately the same rate at pH 10. The rate of E2 rearrangement progressively exceeded that of E1 with a decrease in pH such that at pH 6, E2 rearranged at a rate 15 times that of E1. These data suggested that the cis-Δ5 double bond participated actively in the rearrangement reaction of E2, and was responsible for the greater reactivity of this molecule compared to E1.