The association between salt sensitivity of blood pressure and some polymorphic factors
The association between salt sensitivity of blood pressure and some polymorphic factors
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血压盐敏感性与部分多态性因素的关系
DOI：
10.1097/00004872-199407000-00011
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发表时间：
1994
影响因子：
4.9
通讯作者：
Y. Yamori
中科院分区：
文献类型：
--
作者：
S. Kojima;T. Inenaga;H. Matsuoka;M. Kuramochi;T. Omae;Y. Nara;Y. Yamori
目的研究日本人血压盐敏感性与多态性因子之间的关系。设计与方法根据血压对限盐的反应将104例原发性高血压患者分为盐敏感型和非盐敏感型。血管紧张素转换酶（ACE）基因的插入/缺失多态性进行了检查，通过检测内含子16中的alu序列。ACE基因型根据每个等位基因是否具有该序列而被分类为II、ID或DD。用淀粉凝胶电泳法测定结合珠蛋白表型，将其分为1-1型、2-1型和2-2型。结果血浆肾素活性对盐限制的反应在DD型患者中高于其他型患者，但盐敏感与非盐敏感患者的比例在3个ACE基因型组中无显著差异。然而，结合珠蛋白2-1表型组中的比率显著大于2-2组。结论血压盐敏感性与结合珠蛋白表型有关，而与ACE基因型无关。然而，血浆肾素活性对盐限制的反应根据ACE基因型而不同。
Objective To examine the association in Japanese subjects between the salt sensitivity of blood pressure and polymorphic factors. Design and methods One hundred and four patients with essential hypertension were classified as salt-sensitive or non-salt-sensitive depending on their blood pressure response to salt restriction. An insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene was examined by detecting an alu sequence in intron 16. The ACE genotype was classified as II, ID or DD depending on whether each allele had this sequence. The haptoglobin phenotype was determined by the starch–gel electrophoresis method, and was classified as three phenotypes, 1–1, 2–1 or 2–2 form. Results The response of plasma renin activity to salt restriction was greater in patients with the DD form than in those with other forms, although there were no significant differences in the ratio salt-sensitive: non-salt-sensitive patients among the three ACE genotype groups. However, the ratio was significantly larger in the haptoglobin 2–1 phenotype group than in the 2–2 group. Conclusions The salt sensitivity of blood pressure was associated with the haptoglobin phenotype, but was not associated with the ACE genotype. However, the response of plasma renin activity to salt restriction was different according to the ACE genotype.