AGE-RELATED AND SEX-RELATED BEHAVIOR OF GASTRIC-ACID SECRETION AT THE POPULATION-LEVEL
AGE-RELATED AND SEX-RELATED BEHAVIOR OF GASTRIC-ACID SECRETION AT THE POPULATION-LEVEL
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DOI：
10.3109/00365528209181087
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发表时间：
1982-01-01
影响因子：
1.9
通讯作者：
SIURALA, M
中科院分区：
文献类型：
--
作者：
KEKKI, M;SAMLOFF, IM;SIURALA, M
对计算机筛选的72例先证者及其365例亲属共437例进行了五肽胃泌素刺激的胃酸分泌及胃窦和体部粘膜的组织学检查。上腹部不适、消化性溃疡、裂孔疝气的发生率和血型分布与一般人群相似。产酸量以每公斤体重(TBW)、每公斤体重(TBW)、每公斤瘦体重(LBM)和每公斤脱脂体重(FFB)为单位，与体黏膜的变化相关，而与胃窦的变化无关。当以mmol/h或mmol/hTBW表示时，女性的产酸量低于男性，但以FFB表示时则不是，这比LBM更好地解释了胃表面积的变化，并以这种方式解释了壁细胞团的变化。女性较低的产酸量可能是由于较小的胃表面积和相应较小的壁细胞团，而不是因为细胞对刺激的反应性较低。男性和女性的产酸量随着年龄的增长而减少，这是由于伴随而来的身体粘膜萎缩变化的发生率和严重程度的增加。在身体粘膜正常的男性中，与年龄相关的产酸量下降并不明显。然而，在身体粘膜正常的女性中，以FFB表示的输出量随着年龄的增长而显著增加。这一增长的原因尚不清楚。在患有体黏膜浅表性胃炎的男性和女性中，无论使用哪种配方，产酸量都会随着年龄的增长而减少。
Pentagastrin-stimulated gastric acid output and the histology of the antral and body mucosa were examined in 72 computer-selected probands and their 365 relatives, altogether 437 cases. The frequencies of upper abdominal complaints, peptic ulcer and hiatal hernia and blood group distribution were comparable with those of the population at large. Acid output, expressed as mmol/h, mmol/h per kg of total body weight (TBW), mmol/h per kg of lean body mass (LBM) and mmol/h per kg of fat-free body weight (FFB), correlated with the changes in the body mucosa but not with those in the antrum. Acid output was lower in females than in males when expressed as mmol/h or mmol/h TBW but not when expressed in terms of FFB, which better than LBM accounts for the variation in the gastric surface area and, in this manner, for that of the parietal cell mass. The lower acid output in females is probably due to a smaller gastric surface area and correspondingly smaller parietal cell mass rather than to a lower reactivity of the cells to stimulation. Acid output decreased with increasing age in both sexes and this was due to a concomitant increase in the incidence and severity of atrophic changes in the body mucosa. An age-related decrease in acid output was not seen in males with a normal body mucosa. In females with a normal body mucosa, however, output expressed in terms of FFB showed a significant increase with age. The reason for this increase is not clear. In males and females with superficial gastritis of the body mucosa, acid output decreased with increasing age regardless of the formulation used.