Treatment of periodontitis and endothelial function
Treatment of periodontitis and endothelial function
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DOI：
10.1056/nejmoa063186
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发表时间：
2007-03-01
影响因子：
158.5
通讯作者：
Deanfield, John
中科院分区：
文献类型：
--
作者：
Tonetti, Maurizio S.;D'Aiuto, Francesco;Deanfield, John
背景：全身性炎症可能损害血管功能，流行病学数据表明牙周炎和心血管疾病之间可能存在联系。方法：我们随机将120例重度牙周炎患者分为社区牙周护理组(59例)和强化牙周治疗组(61例)。结果：治疗后24小时，强化治疗组血流介导的内皮功能明显低于对照组(绝对差值为1.4%；95%可信区间[CI]为0.5~2.3；P=0.002)，C-反应蛋白、白介素6、血管内皮细胞活化标志物sE-选择素、von Willebrand因子水平显著升高(P
BACKGROUND:Systemic inflammation may impair vascular function, and epidemiologic data suggest a possible link between periodontitis and cardiovascular disease.METHODS:We randomly assigned 120 patients with severe periodontitis to community-based periodontal care (59 patients) or intensive periodontal treatment (61). Endothelial function, as assessed by measurement of the diameter of the brachial artery during flow (flow-mediated dilatation), and inflammatory biomarkers and markers of coagulation and endothelial activation were evaluated before treatment and 1, 7, 30, 60, and 180 days after treatment.RESULTS:Twenty-four hours after treatment, flow-mediated dilatation was significantly lower in the intensive-treatment group than in the control-treatment group (absolute difference, 1.4%; 95% confidence interval [CI], 0.5 to 2.3; P=0.002), and levels of C-reactive protein, interleukin-6, and the endothelial-activation markers soluble E-selectin and von Willebrand factor were significantly higher (P