Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes.
Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes.
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DOI：
10.1016/j.jcin.2012.03.018
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发表时间：
2012-07
影响因子：
11.3
通讯作者：
Lopes, Renato D.
中科院分区：
文献类型：
--
作者：
Truffa, Adriano A. M.;Granger, Christopher B.;White, Kyle R.;Newby, L. Kristin;Mehta, Rajendra H.;Hochman, Judith S.;Patel, Manesh R.;Pieper, Karen S.;Al-Khalidi, Hussein R.;Armstrong, Paul W.;Lopes, Renato D.
Little is known about the incidence, location, etiologic organisms, and outcomes of infection in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). To address this knowledge gap using the database of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. We also assessed the association between serious infections and 90-day death or death/MI. We analyzed data from 5745 STEMI patients enrolled in the APEX-AMI trial. Detailed information on infection was collected on all patients. We describe characteristics of patients according to infection and details of infection. Cox proportional hazards models were used to assess 90-day outcomes among patients with and without infections after adjusting for associated clinical variables and using infection as a time-dependent covariate. Overall, 138 patients developed a serious infection (2.4%), most of whom presented with a single-site infection. The median (25th, 75th percentile) time until diagnosis of infection was 3 days. The most commonly identified organism was Staphylococcus aureus, and the main location of infection was the bloodstream. These patients had more comorbidities and lower procedural success at index PCI than those without infections. Serious infection was associated with significantly higher rates of 90-day death (adjusted hazard ratio [HR] 5.6; 95% confidence interval [CI] 3.8-8.4) and death or MI (adjusted HR 4.9; 95% CI 3.4-7.1). Infections complicating the course of patients with STEMI are uncommon but associated with markedly worse 90-day clinical outcomes. Mechanisms for early identification of these high-risk patients, as well as design of strategies to reduce their risk of infection, are warranted.
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影响因子：
5.7
作者：
Alfonso, F;Moreno, R;Vergas, J
通讯作者：
Vergas, J
DOI：
10.1080/17482940601178039
发表时间：
2007-01-01
期刊：
Acute cardiac care
影响因子：
--
作者：
Jeger, Raban V;Assmann, Susan F;Hochman, Judith S
通讯作者：
Hochman, Judith S
影响因子：
4.8
作者：
LOFMARK, R;NORDLANDER, R;ORINIUS, E
通讯作者：
ORINIUS, E
影响因子：
3.3
作者：
MCCUE, MJ;MOORE, EE
通讯作者：
MOORE, EE
DOI：
10.1007/s10096-004-1220-7
发表时间：
2004-11-01
影响因子：
4.5
作者：
Rizos, M;Falagas, ME;Michalopoulos, A
通讯作者：
Michalopoulos, A