Tissue response to potential neuroprosthetic materials implanted subdurally.
Tissue response to potential neuroprosthetic materials implanted subdurally.
复制标题
组织对植入硬膜下的潜在神经假体材料的反应。
DOI：
10.1016/0142-9612(87)90103-7
复制
发表时间：
1987
期刊：
影响因子：
14
通讯作者：
Bullara,LA
中科院分区：
文献类型：
--
作者：
Yuen,TG;Agnew,WF;Bullara,LA
A histologie study was made of tho response of the leptomeninges and underlying cerebral cortex of the cat to subdural implantation of 3 insulating materials (HR605-P, Parylene∗-C and PI-2555) and a polymeric electrode component (MMA/MAPTAC) for periods of 8 and 16 wk. The tissue reactions were compared with those elicited by the arrays of Dacron†mesh matrices, pure platinum controls and by positive controls (Ag-AgCI) known to cause reactions in the brain. Sites beneath the Dacron mesh matrix, pure platinum control implants and beneath all insulating materials implanted for 8 and 16 wk appeared indistinguishable, exhibiting little tissue reaction. All neurons appeared normal. The leptomeninges and cortex beneath the Ag-AgCI implants showed a chronic inflammatory reaction after 8 and 16 wk. Despite varying amounts of oedema, gliosis and ingrowth of connective tissue in the molecular layer, virtually all underlying neurons appeared normal.
