Aberration correction by nonlinear beam mixing: generation of a pseudo point sound source.
Aberration correction by nonlinear beam mixing: generation of a pseudo point sound source.
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通过非线性光束混合进行像差校正：伪点声源的生成。
DOI：
10.1109/tuffc.2005.1561666
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Cain,CharlesA
中科院分区：
文献类型：
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作者：
Seo,Jongbum;Choi,JJ;Fowlkes,JBrian;O'Donnell,Matthew;Cain,CharlesA
探索了与微泡的非线性光束混合，以创建用于治疗超声像差校正的伪点源。通过重新审视 Prosperetti 的线性阻尼模型，得出了双频声场驱动的气泡的阻尼系数。因此，双频率的总体阻尼项是通过每个频率的两个阻尼项的线性求和获得的。基于气泡模型的数值模拟表明，从 4 MHz 和 5 MHz 声源生成 1 MHz 频率的最有效尺寸范围是 2.6 至 3.0 /spl mu/m。此外，该尺寸范围构成特定超声造影剂的主要分布。当 0.1% 稀释剂的腔室被 4 MHz 和 5 MHz 声束（它们之间的入射角为 80/spl 度/入射角）声化时，可以在大约 10 cm 外测量到大约 100 Pa、1 MHz 差频信号。此外，接收到的1 MHz差频信号显示出全向特性，尽管两个声束的重叠区域在差频波长的量级上。因此，感应声源可以被认为是伪点源，并且有望用于治疗超声的像差校正。
Nonlinear beam mixing with microbubbles was explored to create a pseudo point source for aberration correction of therapeutic ultrasound. A damping coefficient for a bubble driven by a dual frequency sound field was derived by revisiting Prosperetti's linearized damping model. As a result, the overall damping term for dual frequency was obtained by linear summation of two damping terms for each frequency. The numerical simulation based on the bubble model suggests that the most efficient size range to generate a 1 MHz frequency from 4 MHz and 5 MHz sound sources is 2.6 to 3.0 /spl mu/m. Furthermore, this size range constitutes the primary distribution of a specific ultrasound contrast agent. When a chamber of 0.1% of the diluted agent is sonified by 4 MHz and 5 MHz sound beams with 80/spl deg/ incident angle between them, an approximately 100 Pa, 1 MHz difference frequency signal can be measured approximately 10 cm away. In addition, the received 1 MHz difference frequency signal shows omni-directional characteristics, even though the overlap zone of the two sound beams is on the order of the difference frequency wavelength. Therefore, the induced sound source can be considered as a pseudo point source and is expected to be useful for aberration correction for therapeutic ultrasound.