Portable Biomarker Detection with Magnetic Nanotags.
Portable Biomarker Detection with Magnetic Nanotags.
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DOI：
10.1109/iscas.2010.5537639
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发表时间：
2010-08-03
期刊：
影响因子：
--
通讯作者：
Gaster RS
中科院分区：
文献类型：
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作者：
Hall DA;Wang SX;Murmann B;Gaster RS
本文提出了一种手持式，便携式生物传感器平台的定量生物标志物测量。通过将磁性纳米颗粒（MNP）标签与巨磁阻（GMR）自旋阀传感器相结合，手持式平台在不到20分钟的时间内实现了高灵敏度（皮摩尔）和特异性生物标志物检测。快速分析和潜在的低成本使该技术成为护理点（POC）诊断的理想选择。此外，该平台能够在单一检测中同时检测多种生物标志物，为大量应用创造了有前途的诊断工具。
This paper presents a hand-held, portable biosensor platform for quantitative biomarker measurement. By combining magnetic nanoparticle (MNP) tags with giant magnetoresistive (GMR) spin-valve sensors, the hand-held platform achieves highly sensitive (picomolar) and specific biomarker detection in less than 20 minutes. The rapid analysis and potential low cost make this technology ideal for point-of-care (POC) diagnostics. Furthermore, this platform is able to detect multiple biomarkers simultaneously in a single assay, creating a promising diagnostic tool for a vast number of applications.