Comparison of trace metal concentrations in malign and benign human prostate
Comparison of trace metal concentrations in malign and benign human prostate
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DOI：
10.1021/jm0494568
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发表时间：
2005-01-27
影响因子：
7.3
通讯作者：
Akdeniz, I
中科院分区：
文献类型：
--
作者：
Yaman, M;Atici, D;Akdeniz, I
微量金属的组成不平衡，被认为是人类正常体内平衡所必需的，除了潜在的有毒或非必需的微量金属的积累外，还可能引起疾病。因此，需要在癌性和非癌性人体组织中分析它们，以检查癌症与这些元素之间的关系。采用原子吸收分光光度法测定前列腺组织中Cd、Ni、Zn、Cu、Fe、Mg、Ca等微量金属元素的含量。采用微波能消化组织。与锌的文献数据相反，发现恶性人前列腺中的钙和锌浓度显著高于良性人前列腺中的钙和锌浓度（两种金属均为p < 0.05）。同样，恶性前列腺中铁、镍和镁的浓度也高于良性前列腺（p <0.1）。因此，应该理解的是，需要更多的研究有关的增加或减少的金属（特别是钙和锌）浓度的恶性前列腺样本。
Imbalance in the composition of trace metals, recognized to be essential to normal human homeostasis, besides the accumulation of potentially toxic or nonessential trace metals, may cause disease. Thus, there is a need for their analysis in cancerous and noncancerous human tissues to examine the relationship between cancer and these elements. Trace metal concentrations including Cd, Ni, Zn, Cu, Fe, Mg, and Ca in both malign and benign prostate samples were determined by atomic absorption spectrophotometry. The tissues were digested by using microwave energy. In contrast to the literature data for zinc, the concentrations of calcium and zinc in the malign human prostate were found to be significantly higher than those in the benign human prostate (p < 0.05 for both metals). Similarly, the concentrations of iron, nickel, and magnesium in the malign prostate were also found to be higher than those in the benign prostate (p less than or equal to 0.1). Therefore, it is understood that more studies are needed regarding the increase or decrease in the metal (particularly Ca and Zn) concentrations of malign prostate samples.