Association between serum vitamin D deficiency and age-related macular degeneration in Koreans: Clinical case-control pilot study.
Association between serum vitamin D deficiency and age-related macular degeneration in Koreans: Clinical case-control pilot study.
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DOI：
10.1097/md.0000000000011908
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发表时间：
2018-08
期刊：
影响因子：
1.6
通讯作者：
Park SP
中科院分区：
文献类型：
--
作者：
Kim KL;Park SP
本研究的目的是通过临床病例对照初步研究评估韩国人血清维生素D缺乏与年龄相关性黄斑变性（AMD）之间的关系。该研究包括96名患者：30名晚期AMD患者，32名早期AMD患者和34名正常对照。根据光学相干断层扫描（OCT）图像上是否存在视网膜下纤维化，将晚期AMD患者分为2个亚组。我们在同一季节测定了所有患者血清中的25-羟基维生素D水平，以排除血清维生素D水平的季节性变化。血清维生素D缺乏定义为血清25-羟基维生素D水平低于20 ng/mL。 血清维生素D缺乏倾向于增加早期AMD的风险，尽管具有临界显著性[比值比（OR）= 3.59; 95%置信区间（95%CI）0.95-13.58; P = 0.060]。 它与晚期AMD的更大风险显著相关（OR = 3.61; 95%CI 1.04-12.51; P = 0.043）。 在2个晚期AMD患者亚组中，OCT图像上存在视网膜下纤维化的患者比正常对照组显示出更大的血清维生素D缺乏风险（OR = 7.54; 95%CI 1.34-42.51）。 然而，血清维生素D缺乏与无视网膜下纤维化的晚期AMD之间无显著相关性（OR = 1.89; 95%CI 0.40-8.92）。 血清维生素D缺乏可能增加韩国人早期和晚期AMD的风险，也可能与该人群的视网膜下纤维化有关。
The objective of this study was to evaluate the association between serum vitamin D deficiency and age-related macular degeneration (AMD) in Koreans through a clinical case–control pilot study. The study included 96 patients: 30 with late AMD, 32 with early AMD, and 34 normal controls. The patients with late AMD were divided into 2 subgroups based on the presence or absence of subretinal fibrosis on optical coherence tomography (OCT) images. We measured 25-hydroxyvitamin D levels in the serum of all patients during the same season to rule out seasonal variation of serum vitamin D level. Serum vitamin D deficiency was defined as a serum 25-hydroxyvitamin D level below 20 ng/mL. Serum vitamin D deficiency had a tendency to increase the risk of early AMD, although with borderline significance [odds ratio (OR) = 3.59; 95% confidence interval (95% CI) 0.95–13.58; P = .060]. It was significantly associated with a greater risk of late AMD (OR = 3.61; 95%CI 1.04–12.51; P = .043). Among the 2 subgroups of patients with late AMD, those with subretinal fibrosis present on the OCT images showed a greater risk of serum vitamin D deficiency than the normal controls (OR = 7.54; 95% CI 1.34–42.51). However, there was no significant association between serum vitamin D deficiency and late AMD without subretinal fibrosis (OR = 1.89; 95% CI 0.40–8.92). Serum vitamin D deficiency may increase the risk of early and late AMD in Koreans, and may also be associated with subretinal fibrosis in this population.