Fundamental aspects of the impact of glucocorticoids on the (immature) brain
Fundamental aspects of the impact of glucocorticoids on the (immature) brain
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DOI：
10.1016/j.siny.2008.11.006
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发表时间：
2009-06-01
影响因子：
3
通讯作者：
Joels, Marian
中科院分区：
文献类型：
--
作者：
Champagne, Danielle L.;de Kloet, E. Ronald;Joels, Marian
本文综述了糖皮质激素在脑发育过程中的作用及其对中枢功能的直接影响和长期影响。传统上，这项研究集中在压力和外源性糖皮质激素暴露的有害后果，但远低于发展的能力，尽管暴露于早期逆境的压力恢复力。最近的研究结果表明，早期生活条件的影响是有害的还是保护性的，这取决于后来的环境背景。为了解释这一点，引入了“预测适应性反应”的概念，这意味着早期生活条件可能通过糖皮质激素编程和表型可塑性为未来生活做好准备，目标是“匹配”未来的环境需求。这一概念导致了一种假设，即早期和晚期生活条件之间的“不匹配”会增加对疾病的脆弱性。(C)2008爱思唯尔有限公司保留所有权利。
In this review, studies on the role of glucocorticoids during brain development are recapitulated with reference to their immediate effects and long-term impact on central functions. Traditionally, this research has focused on detrimental consequences of stress and exogenous glucocorticoid exposure but far less on the ability to develop resilience to stress despite exposure to early adversity. Recent findings suggest that the impact of early life conditions turns out as either harmful or protective depending on later environmental context. To explain this, the concept of 'predictive adaptive response' was introduced, implying that early-life conditions may prepare for life ahead through glucocorticoid programming and phenotypic plasticity with the goal to 'match' future environmental demands. This concept has led to the hypothesis that a 'mismatch' between early and later life conditions can enhance vulnerability to disease. (C) 2008 Elsevier Ltd. All rights reserved.