Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma
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DOI：
10.1111/j.1365-2141.2008.07325.x
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发表时间：
2008-10-01
影响因子：
6.5
通讯作者：
Yatomi, Yutaka
中科院分区：
文献类型：
--
作者：
Masuda, Akiko;Nakamura, Kazuhiro;Yatomi, Yutaka
自分泌运动因子（ATX）是一种肿瘤细胞运动刺激因子，最初从黑色素瘤细胞上清液中分离。ATX与溶血磷脂酶D相同，后者从溶血磷脂酰胆碱产生生物活性脂质介质溶血磷脂酸（LPA）。ATX在各种恶性肿瘤中过表达，包括霍奇金淋巴瘤，ATX可通过产生LPA刺激肿瘤进展。本研究使用最近开发的自动化酶免疫分析法测定血液系统恶性肿瘤患者的血清ATX抗原水平。B细胞肿瘤患者，尤其是滤泡性淋巴瘤（FL）患者的血清ATX抗原水平高于健康人。FL患者的血清ATX抗原水平与肿瘤负荷相关，并与患者的临床病程平行变化。与可溶性白细胞介素-2受体和β 2-微球蛋白水平不同，血清ATX抗原水平受炎症的影响很小。FL患者血浆LPA水平与血清ATX抗原水平呈正相关。鉴于FL患者的白血病肿瘤细胞表达ATX，ATX从淋巴瘤细胞脱落可能导致血清ATX抗原水平升高。本研究结果提示，血清ATX抗原水平可能是FL的一个有前景的新指标。
Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. ATX is overexpressed in various malignancies, including Hodgkin lymphoma, and ATX may stimulate tumour progression via LPA production. The present study measured the serum ATX antigen levels in patients with haematological malignancies using a recently developed automated enzyme immunoassay. The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects. Serum ATX antigen levels in FL patients were associated with tumour burden and changed in parallel with the patients' clinical courses. The serum ATX antigen levels were little affected by inflammation, unlike the soluble interleukin-2 receptor and beta 2-microglobulin levels. As expected, the plasma LPA levels in FL patients were correlated with the serum ATX antigen levels. Given that leukaemic tumour cells from FL patients expressed ATX, the shedding of ATX from lymphoma cells probably leads to the elevation of serum ATX antigen levels. Our results suggest that the serum ATX antigen level may be a promising and novel marker for FL.