New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals
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DOI：
10.1038/35036326
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发表时间：
2000-10-01
影响因子：
21.3
通讯作者：
Fujino, M
中科院分区：
文献类型：
--
作者：
Hinuma, S;Shintani, Y;Fujino, M
虽然在无脊椎动物中发现了大量的RFamide多肽，但在哺乳动物中只发现了少数几个RFamide多肽。在这里，我们报告了一个人类基因的鉴定，该基因编码至少三个RFamide相关肽，hRFRP-1-3。转染有7个跨膜区受体0T7T022的细胞对合成的hRFRP-1和hRFRP-3有特异性反应，但对hRFRP-2没有反应。RFRP和0T7T022mRNAs在大鼠下丘脑的特定区域表达，侧脑室注射hRFRP-1可增加大鼠催乳素的分泌。我们的结果表明，哺乳动物体内可能存在多种与RFamide相关的多肽并发挥其功能。
Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, 0T7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and 0T7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.