Cycles of external dependency drive evolution of avian carotenoid networks
Cycles of external dependency drive evolution of avian carotenoid networks
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DOI：
10.1038/s41467-019-09579-y
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发表时间：
2019-04
影响因子：
16.6
通讯作者：
A. Badyaev;Alexander Blaise Posner;Erin S. Morrison;Dawn M. Higginson
中科院分区：
文献类型：
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作者：
A. Badyaev;Alexander Blaise Posner;Erin S. Morrison;Dawn M. Higginson
所有生物体都依赖于不能在内部产生的外源化合物的输入。这种依赖关系的得失构成了生态群落，并推动了物种的进化，但适应这些可变依赖关系的机制的进化仍然难以捉摸。在这里，我们表明，在禽类胡萝卜素生产网络中，外部依赖的得失的历史周期与它们的进化多样性有关。这是因为代谢控制的内部化--当饮食投入的冗余收益与其衍生产品的更多分支同时产生--通过保护现有网络不受投入环境波动的影响，使其能够快速和可持续地探索。相应地，内部控制的丧失限制了进化到饮食前体的得失的速度。由于网络控制的内部化必然会连接网络中特定于饮食的酶模块，因此它在结构上将局部适应和持续进化联系在一起，即使是完全依赖于偶然外部输入的特征也是如此。
All organisms depend on input of exogenous compounds that cannot be internally produced. Gain and loss of such dependencies structure ecological communities and drive species’ evolution, yet the evolution of mechanisms that accommodate these variable dependencies remain elusive. Here, we show that historical cycles of gains and losses of external dependencies in avian carotenoid-producing networks are linked to their evolutionary diversification. This occurs because internalization of metabolic controls—produced when gains in redundancy of dietary inputs coincide with increased branching of their derived products—enables rapid and sustainable exploration of an existing network by shielding it from environmental fluctuations in inputs. Correspondingly, loss of internal controls constrains evolution to the rate of the gains and losses of dietary precursors. Because internalization of a network’s controls necessarily bridges diet-specific enzymatic modules within a network, it structurally links local adaptation and continuous evolution even for traits fully dependent on contingent external inputs.