Breast metastasis of a squamous cell carcinoma of the uterine cervix mimicking inflammatory breast cancer.
Breast metastasis of a squamous cell carcinoma of the uterine cervix mimicking inflammatory breast cancer.
复制标题
DOI：
10.1159/000342255
复制
发表时间：
2012-05
影响因子：
0.8
通讯作者：
Bertucci F
中科院分区：
文献类型：
--
作者：
Sabatier R;Roussin C;Riviere JP;Jalaguier A;Jacquemier J;Bertucci F
远处癌的乳腺转移并不常见，宫颈癌很少是原发灶。我们描述了首例患有类似炎性乳腺癌的宫颈鳞状细胞癌乳腺转移病例，患者为一名 74 岁女性。原发性肿瘤治疗十七个月后，患者出现乳腺病变，看起来像炎性乳腺肿瘤。由于患者拒绝，拖延了1年，病理检查和免疫组化确诊为低分化鳞状细胞癌乳腺转移。乳房体积巨大，伴有腋窝淋巴结肿大和多发性肺转移。尽管进行了铂类化疗，但疾病仍在进展，患者在第一个化疗周期后 3 个月和首次出现乳房症状后 15 个月迅速死亡。我们回顾了有关妇科癌症，特别是宫颈鳞状细胞癌乳腺转移的文献。此类病变的鉴别诊断可能存在问题，但对于避免不必要的残肢手术和采取适当的全身治疗至关重要。预后较差。
Breast metastases from distant carcinoma are infrequent, and cervix carcinoma is rarely the primary lesion. We describe the first case of a cervical squamous cell carcinoma with breast metastasis mimicking an inflammatory breast cancer in a 74-year-old woman. Seventeen months after the treatment of a primary tumor, the patient developed breast lesions looking like an inflammatory breast tumor. After a 1-year delay due to the patient's refusal, pathological examination and immunohistochemistry confirmed the diagnosis of breast metastasis from a poorly differentiated squamous cell carcinoma. The volume of the breast was huge, associated with axillary lymphadenopathies and multiple lung metastases. Despite platinum-based chemotherapy, the disease progressed and the patient died rapidly, 3 months after the first chemotherapy cycle and 15 months after the first mammary symptoms. We review the literature concerning breast metastases from gynecologic cancers and, particularly, from cervical squamous cell carcinoma. Differential diagnosis of such lesions may be problematic but is essential to avoid unnecessary mutilating surgery and to institute the appropriate systemic therapy. The prognosis is poor.