The insatiable quest for near-infrared fluorescent probes for molecular imaging.
The insatiable quest for near-infrared fluorescent probes for molecular imaging.
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DOI：
10.1002/anie.201005684
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发表时间：
2010-12-17
影响因子：
16.6
通讯作者：
Achilefu, Samuel
中科院分区：
文献类型：
--
作者：
Achilefu, Samuel
几个世纪以来，开发新的分子传感器和报告分子的策略一直吸引着研究人员的注意力。这些分子探针在化学、生物学和医学领域的许多开创性发现中发挥了重要作用。直到最近，大多数可用的染料在可见光波长下是光活性的，并且分析仪器被优化以用于该区域。虽然可见光染料在各种研究努力中继续发挥重要作用，但是生物体中分子过程的光学成像的出现激发了开发用于近红外（NIR）区域的分子探针的兴趣，典型地在700纳米和900纳米之间。在该光谱窗口中，许多内在组织发色团、大分子和细胞器具有低的光吸收、自发荧光和光散射。净效应是NIR光可以相对于可见光波长在组织中穿透得更深，从而能够评估几个组织层中的分子和生理事件。为了利用近红外光学分子成像的优势，在过去十年中，开发新的近红外成像方法和分子探针（图1）的共同努力激增。
Strategies to develop new molecular sensors and reporters have captivated the attention of researches for many centuries. These molecular probes have been instrumental to many pioneering discoveries in chemistry, biology, and medicine. Until recently, most of the available dyes were photoactive at the visible wavelengths and analytical instruments were optimized for use in this region.Although visible dyes continue to play important roles in various research endeavours, the advent of optical imaging of molecular processes in living organisms has stimulated interest in developing molecular probes for use in the near-infrared (NIR) region, typically between 700 nm and 900 nm. In this spectral window, many intrinsic tissue chromophores, macromolecules, and organelles have low light absorption, autofluorescence, and light scattering. The net effect is that NIR light can penetrate much deeper in tissue relative to the visible wavelengths, enabling the assessment of molecular and physiological events in several tissue layers. To harness the advantages of NIR optical molecular imaging, concerted efforts to develop new NIR imaging methods and molecular probes (Figure 1) have surged in the last decade.
影响因子：
15
作者：
Ma, Nan;Marshall, Ann F.;Rao, Jianghong
通讯作者：
Rao, Jianghong
影响因子：
46.9
作者：
So, MK;Xu, CJ;Rao, JH
通讯作者：
Rao, JH
影响因子：
48
作者：
Shcherbo, Dmitry;Shemiakina, Irina I.;Ryabova, Anastasiya V.;Luker, Kathryn E.;Schmidt, Bradley T.;Souslova, Ekaterina A.;Gorodnicheva, Tatiana V.;Strukova, Lydia;Shidlovskiy, Konstantin M.;Britanova, Olga V.;Zaraisky, Andrey G.;Lukyanov, Konstantin A.;Loschenov, Victor B.;Luker, Gary D.;Chudakov, Dmitriy M.
通讯作者：
Chudakov, Dmitriy M.