Distribution of unipolar brush cells and other calretinin immunoreactive components in the mammalian cerebellar cortex
Distribution of unipolar brush cells and other calretinin immunoreactive components in the mammalian cerebellar cortex
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DOI：
10.1023/a:1007072105919
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发表时间：
1999-02-01
期刊：
影响因子：
--
通讯作者：
Mugnaini, E
中科院分区：
文献类型：
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作者：
Diño, MR;Willard, FH;Mugnaini, E
我们用单极刷状细胞(UBC)在巴西负鼠、小鼠、豚鼠、兔、猫和恒河猴小脑中的分布进行了比较。UBC的形态和Calretinin染色强度在不同物种之间保持不变。作为一个总的趋势，在所有被研究的物种中，UBC在前庭小脑中尤其丰富。然而，UBC在小脑皮质其他区域的分布存在物种间差异。一个主要的变异涉及到副丘脑腹侧富含UBC的区域的范围。UBC在非前庭春叶中的分布也有很大差异。在负鼠、兔子、猫和猕猴的蠕虫中，UBC或多或少分布在不同的矢状面旁区域。UBC的密度从同一小叶的内侧向外侧递减，在小脑半球的外侧、后部(小腿II)和小脑旁的背部密度最低。在猫和猕猴中，跨越中间皮质的UBC密度的下降比其他物种的UBC密度下降更缓慢。这些数据表明，在肉食性动物和灵长类动物中，UBC在调节感觉-运动转换中的作用比在较小的哺乳动物中更显著，不应被认为是神经元的一种残留形式。除UBC外，Calretinin抗体还可明显标记不同物种中的下列神经元：除兔和猫以外的所有物种的颗粒细胞和平行纤维；高尔基细胞，尤其是大鼠和猕猴；卢加罗样细胞，特别是小鼠、大鼠和猕猴；猕猴的篮状细胞；所有物种的苔藓纤维亚群；以及除豚鼠外的所有物种的攀缘纤维亚群。通常，UBC的分布与Calretinin染色的颗粒细胞和苔藓纤维的分布有关。
We have compared the distribution of unipolar brush cells (UBCs) in the cerebellum of Brazilian opossum (Monodelphis domestica), mouse, guinea pig, rabbit, cat, and Rhesus monkey, using an antiserum to calretinin which is present in those cells. The morphology and calretinin staining intensity of the UBCs remains constant across species. As a general trend, in all species studied, UBCs are particularly enriched in the vestibulocerebellum. Interspecies differences, however, were noted in the distribution of UBCs across other regions of the cerebellar cortex. A major variation involves the extent of the UBC-rich region of the ventral portion of the paraflocculus. The distribution of UBCs in non-vestibular vermal folia also varies substantially. UBCs are deployed in more or less distinct parasagittal zones in the vermis of the opossum, rabbit, cat, and macaque. The density of UBCs decreases progressively from medial to lateral portions of the same folium and is lowest in the lateral, posterior portions of the cerebellar hemispheres (crus II) and in the dorsal portion of the paraflocculus. In cat and macaque, the decrease in the density of UBCs across the intermediate cortex is more gradual than in the other species. The data indicate that the UBCs play a more prominent role in the modulation of sensorimotor transformations in carnivores and primates than in smaller mammals and should not be considered a vestigial form of neuron. In addition to the UBCs, calretinin antibody distinctly stains the following neurons in different species: granule cells and parallel fibers in all species except rabbit and cat; Golgi cells, especially in rat and macaque; Lugaro-like cells, especially in mouse, rat, and macaque; basket cells in macaque; subsets of mossy fibers in all species; and subsets of climbing fibers in all species but guinea pig. Usually, the distribution of UBCs is related to that of calretinin stained granule cells and mossy fibers.