Chromosome Alignment and Transvection Are Antagonized by Condensin II
Chromosome Alignment and Transvection Are Antagonized by Condensin II
复制标题
DOI：
10.1126/science.1164216
复制
发表时间：
2008-11-28
期刊：
影响因子：
56.9
通讯作者：
Bosco, Giovanni
中科院分区：
文献类型：
--
作者：
Hartl, Tom A.;Smith, Helen F.;Bosco, Giovanni
多线染色体结构是一些多倍体细胞的特征，其中几个到数千个染色单体与同源DNA序列的完美排列密切相关。在这里，我们表明果蝇凝聚素II促进多烯结构分解成染色体成分。凝缩蛋白II也负调控横切，即某些等位基因通过等位基因间的物理关联在转录上受到影响。我们认为凝缩蛋白II限制了影响转录的反染色体相互作用，通过其空间分离排列的间期染色体的能力。
Polytene chromosome structure is a characteristic of some polyploid cells where several to thousands of chromatids are closely associated with perfect alignment of homologous DNA sequences. Here, we show that Drosophila condensin II promotes disassembly of polytene structure into chromosomal components. Condensin II also negatively regulates transvection, a process whereby certain alleles are influenced transcriptionally via interallelic physical associations. We propose that condensin II restricts trans- chromosomal interactions that affect transcription through its ability to spatially separate aligned interphase chromosomes.