Integrated view of Vibrio cholerae in the Americas
Integrated view of Vibrio cholerae in the Americas
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DOI：
10.1126/science.aao2136
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发表时间：
2017-11-10
期刊：
影响因子：
56.9
通讯作者：
Thomson, Nicholas R.
中科院分区：
文献类型：
--
作者：
Domman, Daryl;Quilici, Marie-Laure;Thomson, Nicholas R.
拉丁美洲经历了现代历史上两次最严重的霍乱疫情；一次发生在 1991 年，另一次发生在 2010 年。然而，全球流行的霍乱弧菌克隆与当地细菌种群之间的关系仍然令人困惑。我们使用全基因组测序来描述 40 年时间跨度内美洲霍乱的特征。我们发现，这两种流行病都是第七次大流行埃尔托霍乱弧菌跨洲传入的结果，并且美洲本地至少有七个谱系与流行病学上与流行性霍乱不同的疾病有关。我们的研究结果将大流行性霍乱的历史记录与数据相结合，以显示当地谱系的重要性，提出了对未来疾病控制策略的设计非常重要的霍乱综合观点。
Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.