Rising incidence of oral tongue cancer among white men and women in the United States, 1973-2012
Rising incidence of oral tongue cancer among white men and women in the United States, 1973-2012
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DOI：
10.1016/j.oraloncology.2017.02.019
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发表时间：
2017-04-01
期刊：
影响因子：
4.8
通讯作者：
Chaturvedi, Anil K.
中科院分区：
文献类型：
--
作者：
Tota, Joseph E.;Anderson, William F.;Chaturvedi, Anil K.
背景资料：尽管美国的烟草使用显著减少，但据报道，近年来口腔舌癌的发病率有所增加，特别是在年轻的白色女性中。我们进行了年龄段队列分析，以确定口腔舌癌发病率增加的出生队列，并将这些与口咽癌的趋势进行比较，口咽癌是一种由人乳头瘤病毒（HPV）引起的癌症，最近也有所增加。方法：我们利用癌症发病率数据（1973-2012年）来自NCI SEER计划维护的18个登记处。使用对数线性连接点回归评估发病率趋势，并使用年龄-时期-队列模型同时评估年龄、日历年和出生年份对发病率趋势的影响。1973-2012年间，白色女性口腔舌癌发病率显著增加（年增长率0.6%，p < 0.001）和白色男性（年增长率5.1%，p = 0.004）。这种增长在年轻的白色个体中最为明显（< 50岁; 1973-2012年期间，男性每年增长0.7%[p = 0.02]，女性每年增长1.7%[p < 0.001]）。此外，1973年至2012年期间，年轻白色男性和女性的增加幅度相似（分别为每百万人2.3例和1.8例）。口咽癌的发病趋势与口腔舌癌和类似出生队列的发病趋势相似（20世纪40年代以后出生的人）经历了这些癌症的发病率上升（p值：白色男性= 0.12，白色女性= 0.42），尽管口咽癌的增加幅度更大。在美国，同一出生队列的年轻白色男性和女性中，口腔舌癌和口咽癌的发病率显著增加。爱思唯尔有限公司出版
Background: Despite significant reductions in tobacco use in the US, oral tongue cancer incidence has reportedly increased in recent years, particularly in young white women. We conducted age-periodcohort analyses to identify birth cohorts that have experienced increased oral tongue cancer incidence, and compared these with trends for oropharyngeal cancer, a cancer caused by human papillomavirus (HPV) that has also recently increased.Methods: We utilized cancer incidence data (1973-2012) from 18 registries maintained by the NCI SEER Program. Incidence trends were evaluated using log-linear joinpoint regression and age-period-cohort modeling was utilized to simultaneously evaluate effects of age, calendar year, and birth year on incidence trends.Results: Incidence of oral tongue cancer increased significantly among white women during 1973-2012 (0.6% annual increase, p < 0.001) and white men during 2008-2012 (5.1% annual increase, p = 0.004). The increase was most apparent among younger white individuals (< 50 years; annual increase of 0.7% for men [p = 0.02] and 1.7% for women [p < 0.001] during 1973-2012). Furthermore, the magnitude of the increase during 1973-2012 was similar between young white men and women (2.3 vs. 1.8 cases per million, respectively). Incidence trends for oropharyngeal cancer were similar to trends for oral tongue cancer and similar birth cohorts (born after the 1940s) experienced rising incidence of these cancers (p-value: white men = 0.12, white women = 0.42), although the magnitude of increase was greater for oropharyngeal cancer.Conclusions: The incidence of oral tongue and oropharyngeal cancer has significantly increased among young white men and women within the same birth cohorts in the US. Published by Elsevier Ltd.