Risk of Birth Defects Increased in Multiple Births
Risk of Birth Defects Increased in Multiple Births
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DOI：
10.1002/bdra.20725
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发表时间：
2011-01-01
影响因子：
--
通讯作者：
Huang, Jiang-Ping
中科院分区：
文献类型：
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作者：
Zhang, Xiao-Hui;Qiu, Li-Qian;Huang, Jiang-Ping
背景：以前的研究不一致地表明出生缺陷和多胎之间可能存在关联。方法：数据来源于2007 - 2009年浙江省医院出生缺陷监测系统。总共有545,018例怀孕，其中包括537,593例单胎妊娠和7425例多胎妊娠（14,606例双胞胎和366例三胞胎）。计算单胎和多胎出生缺陷的优势比（OR）和置信区间（CI）。结果：多胞胎的出生缺陷率为444.16 / 10,000，而单胞胎的出生缺陷率为266.97 / 10,000 （OR, 1.69; 95% CI, 1.57-1.84）。在23类多胞胎中，有9类存在显著的出生缺陷风险。多胞胎和有先天缺陷的单胞胎的单畸形、男婴和母亲居住在城市的比例相似。出生缺陷的多胞胎分娩时间较出生缺陷的单胞胎早（t = 7.90, p < 0.001），出生体重较低（t = 17.53, p < 0.001）。与多胞胎相比，单胎的产前诊断比例更高（p < 0.001）。出生缺陷多胞胎的活产和新生儿早期死亡比例较高（p < 0.001）。结论：与单胎相比，多胎出生缺陷的风险增加已得到证实。出生缺陷研究（A辑）91:34-38,2011。(C) 2010 Wiley-Liss, Inc。
BACKGROUND: Previous studies inconsistently suggest that there may be an association between birth defects and multiple births. METHODS: Data were obtained from Zhejiang Hospital-Based Birth Defects Surveillance System during 2007 to 2009. There was a total of 545,018 pregnancies, including 537,593 singleton pregnancies, and 7425 multiple pregnancies (14,606 twins and 366 triplets). Odds ratio (OR) and confidence interval (CI) for birth defects were calculated for the singletons and multiple births. RESULTS: The rate of birth defects in multiple births was 444.16 per 10,000 births versus 266.97 per 10,000 births in singletons (OR, 1.69; 95% CI, 1.57-1.84). A significant risk of birth defects was observed in 9 of 23 categories in multiple births. Both the multiple births and singletons with birth defects exhibited a similar proportion of single malformation, male children, and the mother living in a city. The multiple births with birth defects were delivered earlier (t = 7.90, p < 0.001) at a lower birth weight (t = 17.53, p < 0.001) compared to singletons with birth defects. The proportion of an antenatal diagnosis was higher in singletons compared with multiple births (p < 0.001). The multiple births with birth defects had a higher proportion of live birth and early neonatal death (p < 0.001). CONCLUSIONS: An increased risk of birth defects in multiple births compared with singletons was confirmed. Birth Defects Research (Part A) 91:34-38, 2011. (C) 2010 Wiley-Liss, Inc.