1H and 13C NMR Studies of Formation and Molecular Dynamics of Methylated-Cyclodextrin Inclusion Complexes with Phenylalanine
1H and 13C NMR Studies of Formation and Molecular Dynamics of Methylated-Cyclodextrin Inclusion Complexes with Phenylalanine
复制标题
甲基化环糊精与苯丙氨酸包合物的形成和分子动力学的 1H 和 13C NMR 研究
DOI：
10.1246/bcsj.60.2539
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发表时间：
1987
影响因子：
4
通讯作者：
R. Chǔjǒ
中科院分区：
文献类型：
--
作者：
Y. Inoue;Fu;R. Chǔjǒ
用~1H和~(13)C核磁共振法研究了主体α和全甲基化α-环糊精、全甲基化β-环糊精和客体苯丙氨酸在水溶液中主客体包合物的形成和分子动力学。加入主体环糊精后，客体苯丙氨酸的~1H化学位移、~1H自旋耦合常数和~(13)C自旋-晶格驰豫时间的变化表明，它们以相似的方式形成包合物，即通过将客体的苯环插入到主体的空腔中。主客体动态耦合强度随环糊精空腔尺寸的不同而不同。
The formation and the molecular dynamics of the host-guest inclusion complexes in aqueous solution have been studied for hosts α- and permethylated α-cyclodextrin and permethylated β-cyclodextrin and guest phenylalanine by 1H and 13C NMR spectroscopy. The changes in 1H chemical shift, 1H spin-coupling constant, and 13C spin-lattice relaxation time for the guest phenylalanine on addition of the host cyclodextrin show that they form the inclusion complexes in a similar manner, that is, by insertion of the guest’s phenyl ring into the host’s cavity. The strength of the host–guest dynamic coupling varies with the cavity size of cyclodextrins.