PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report
PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report
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PET - CT 扫描显示自体细胞治疗后自闭症严重程度降低：病例报告
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
A. Paranjape
中科院分区：
文献类型：
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作者：
A. Sharma;H. Sane;ini Gokulch;P. Badhe;Avantika Patil;P. Kulkarni;A. Paranjape
PET - CT扫描最近已被用于检测大脑中的功能异常。在自闭症中，大脑的MRI是正常的，因此，应该探索功能性神经成像技术，如正电子发射断层扫描-计算机断层扫描。自闭症是一种复杂的神经发育障碍，影响沟通，行为和社会化。目前，可用的治疗方法旨在症状变化，而不是针对自闭症大脑中的核心病理。细胞疗法最近已成为自闭症的一种有前途的治疗方式。然而，细胞治疗的效果需要通过客观成像来监测。在这项研究中，我们介绍了一个6岁的自闭症男孩的情况下，鞘内注射自体骨髓单核细胞和监测正电子发射断层扫描-计算机断层扫描。在3个月和6个月的定期随访中，观察到显著的社会，行为和沟通改善。在结果测量方面，印度自闭症评估量表评分从干预前的113提高到97，功能独立性测量从42提高到50，儿童自闭症评定量表从42. 5提高到35. 5。临床总体印象量表的疾病严重程度评分从5分（明显疾病）变为4分（中度疾病）。CGI量表上的总体改善评分为2（显著改善）。儿童孤独症评定量表的疗效指数为中度疗效（5分）。有趣的是，6个月时的正电子发射断层扫描-计算机断层扫描比较显示，先前低代谢的大脑区域的代谢改善，这与临床改善密切相关。未报告不良事件。
PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography - Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography - Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre - intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported.
DOI：
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发表时间：
2012-03
期刊：
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影响因子：
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作者：
J. Baio
通讯作者：
J. Baio