Chemotherapy-induced peripheral neuropathy: an update on the current understanding.
Chemotherapy-induced peripheral neuropathy: an update on the current understanding.
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DOI：
10.12688/f1000research.8053.1
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Freimer, Miriam
中科院分区：
文献类型：
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作者：
Addington, James;Freimer, Miriam
化疗所致的周围神经病变是化疗药物常见的副作用。以前的工作表明，患者经常漏报化疗引起的周围神经病变的症状，医生没有及时认识到这种症状的存在。在急性期和慢性期，化疗引起的周围神经病变的确切病理生理学基础仍然复杂，而且似乎是药物特有的。最近的工作已经开始证明并进一步阐明可能的病理生理过程，这些过程易于并最终导致化疗引起的周围神经病变的发展。越来越多的证据表明，每种药物导致神经病变的途径都不同。随着对这些药物如何影响周围神经系统的更清楚的了解，可以开发更有针对性的治疗方法，以优化治疗并防止长期副作用。
Chemotherapy-induced peripheral neuropathy is a common side effect of selected chemotherapeutic agents. Previous work has suggested that patients often under report the symptoms of chemotherapy-induced peripheral neuropathy and physicians fail to recognize the presence of such symptoms in a timely fashion. The precise pathophysiology that underlies chemotherapy-induced peripheral neuropathy, in both the acute and the chronic phase, remains complex and appears to be medication specific. Recent work has begun to demonstrate and further clarify potential pathophysiological processes that predispose and, ultimately, lead to the development of chemotherapy-induced peripheral neuropathy. There is increasing evidence that the pathway to neuropathy varies with each agent. With a clearer understanding of how these agents affect the peripheral nervous system, more targeted treatments can be developed in order to optimize treatment and prevent long-term side effects.