Extracellular Matrix, a Hard Player in Angiogenesis.
Extracellular Matrix, a Hard Player in Angiogenesis.
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DOI：
10.3390/ijms17111822
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发表时间：
2016-11-01
影响因子：
5.6
通讯作者：
Paulitti A
中科院分区：
文献类型：
--
作者：
Mongiat M;Andreuzzi E;Tarticchio G;Paulitti A
细胞外基质（ECM）是由蛋白质、糖蛋白、蛋白聚糖和多糖组成的复杂网络。ECM通过与细胞表面受体的相互作用，不仅决定了组织的物理和机械特性，而且还深刻地影响了细胞行为和许多生理和病理过程。其中一个已被广泛研究的功能是其对血管生成的影响。在这种情况下，ECM的强烈影响是直接和间接的，因为它能够相互作用和/或储存几种生长因子和细胞因子。这篇综述的目的是提供这些分子在促进或减弱血管生成过程中引起的复杂分子机制的一些例子。这种情况是复杂的，因为基质重塑通常会产生与整个分子所产生的效果相反的片段。因此，根据组成给定组织基质的促或抗血管生成分子/片段的相对表达，平衡将向血管生成或血管抑制倾斜。该研究领域的一个重要方面是，由于其内源性，ECM可以被视为一个水库，以开发新的更有效的治疗血管生成依赖性病变的疗法。
The extracellular matrix (ECM) is a complex network of proteins, glycoproteins, proteoglycans, and polysaccharides. Through multiple interactions with each other and the cell surface receptors, not only the ECM determines the physical and mechanical properties of the tissues, but also profoundly influences cell behavior and many physiological and pathological processes. One of the functions that have been extensively explored is its impingement on angiogenesis. The strong impact of the ECM in this context is both direct and indirect by virtue of its ability to interact and/or store several growth factors and cytokines. The aim of this review is to provide some examples of the complex molecular mechanisms that are elicited by these molecules in promoting or weakening the angiogenic processes. The scenario is intricate, since matrix remodeling often generates fragments displaying opposite effects compared to those exerted by the whole molecules. Thus, the balance will tilt towards angiogenesis or angiostasis depending on the relative expression of pro- or anti-angiogenetic molecules/fragments composing the matrix of a given tissue. One of the vital aspects of this field of research is that, for its endogenous nature, the ECM can be viewed as a reservoir to draw from for the development of new more efficacious therapies to treat angiogenesis-dependent pathologies.
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影响因子：
3.7
作者：
Boivin WA;Shackleford M;Vanden Hoek A;Zhao H;Hackett TL;Knight DA;Granville DJ
通讯作者：
Granville DJ
影响因子：
6.9
作者：
Berendsen, Agnes D.;Pinnow, Emily L.;Maeda, Azusa;Brown, Aaron C.;McCartney-Francis, Nancy;Kram, Vardit;Owens, Rick T.;Robey, Pamela G.;Holmbeck, Kenn;de Castro, Luis F.;Kilts, Tina M.;Young, Marian F.
通讯作者：
Young, Marian F.
影响因子：
9.8
作者：
Astrof S;Hynes RO
通讯作者：
Hynes RO
DOI：
10.1093/jnci/djj441
发表时间：
2006-11-15
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Bix, Gregory;Castello, Remedios;Iozzo, Renato V.
通讯作者：
Iozzo, Renato V.
DOI：
10.1073/pnas.95.11.6355
发表时间：
1998-05-26
影响因子：
11.1
作者：
Babic, AM;Kireeva, ML;Lau, LF
通讯作者：
Lau, LF