Development and Application of Cochlear Implant-Based Electric-Acoustic Stimulation of Spiral Ganglion Neurons
Development and Application of Cochlear Implant-Based Electric-Acoustic Stimulation of Spiral Ganglion Neurons
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DOI：
10.1021/acsbiomaterials.9b01265
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发表时间：
2019-12-01
影响因子：
5.8
通讯作者：
Tang, Mingliang
中科院分区：
文献类型：
--
作者：
Guo, Rongrong;Ma, Xiaofeng;Tang, Mingliang
耳蜗植入物是目前治疗深度感音神经性听力损失最有效的方法。然而，它们的治疗效果受到螺旋神经节神经元（SGN）的存活和适当生理功能的限制，螺旋神经节神经元是耳蜗植入物的靶向。因此，探索电声刺激（EAS）对靶向SGN的作用机制至关重要。在这项工作中，生物相容性人工耳蜗植入物/石墨烯EAS系统是通过结合人工耳蜗植入物，以提供电转换的声音刺激与石墨烯作为导电神经接口创建的。SGN在石墨烯上培养并暴露于来自耳蜗植入物的EAS。长期刺激可促进SGN神经突的延伸，这可能有助于生长锥的发育。我们的系统使我们能够以低成本和节省时间的方式研究人工耳蜗植入物对SGN的影响，这可能会为人工耳蜗植入物的使用提供深刻的见解，从而对患有感音神经性听力损失的人群有益。
Cochlear implants are currently the most effective treatment for profound sensorineural hearing loss. However, their therapeutic effect is limited by the survival and proper physiological function of spiral ganglion neurons (SGNs), which are targeted by the cochlear implant. It is therefore critical to explore the mechanism behind the effect of electric-acoustic stimulation (EAS) on the targeted SGNs. In this work, a biocompatible cochlear implant/graphene EAS system was created by combining a cochlear implant to provide the electrically transformed sound stimulation with graphene as the conductive neural interface. SGNs were cultured on the graphene and exposed to EAS from the cochlear implant. Neurite extension of SGNs was accelerated with long-term stimulation, which might contribute to the development of growth cones. Our system allows us to study the effects of cochlear implants on SGNs in a low-cost and time-saving way, and this might provide profound insights into the use of cochlear implants and thus be of benefit to the populations suffering from sensorineural hearing loss.