PERFORMING THE EXACT TEST OF HARDY-WEINBERG PROPORTION FOR MULTIPLE ALLELES
PERFORMING THE EXACT TEST OF HARDY-WEINBERG PROPORTION FOR MULTIPLE ALLELES
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DOI：
10.2307/2532296
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发表时间：
1992-06-01
期刊：
影响因子：
1.9
通讯作者：
THOMPSON, EA
中科院分区：
文献类型：
--
作者：
GUO, SW;THOMPSON, EA
Hardy-Weinberg定律在群体遗传学领域中起着重要的作用，经常作为遗传推断的基础。由于其重要性，几十年来，人们对Hardy-Weinberg比例（HWP）的测试给予了很大的关注。人们早就认识到，当样本量和/或某些基因型频率很小时，大样本拟合优度检验有时会导致虚假的结果。虽然已经提出了精确测试的完整枚举算法，但由于所需的计算量，它对于具有多个等位基因的位点并不具有实际用途。我们提出了两种算法来估计HWP检验的显著性水平。该算法易于应用于具有多个等位基因的基因座。两者都非常简单且计算速度快。比较了两种算法的相对效率和优点。给出了它们的使用指南。数值算例说明了算法的实用性。
The Hardy-Weinberg law plays an important role in the field of population genetics and often serves as a basis for genetic inference. Because of its importance, much attention has been devoted to tests of Hardy-Weinberg proportions (HWP) over the decades. It has long been recognized that large-sample goodness-of-fit tests can sometimes lead to spurious results when the sample size and/or some genotypic frequencies are small. Although a complete enumeration algorithm for the exact test has been proposed, it is not of practical use for loci with more than a few alleles due to the amount of computation required. We propose two algorithms to estimate the significance level for a test of HWP. The algorithms are easily applicable to loci with multiple alleles. Both are remarkably simple and computationally fast. Relative efficiency and merits of the two algorithms are compared. Guidelines regarding their usage are given. Numerical examples are given to illustrate the practicality of the algorithms.