Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles
Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles
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DOI：
10.1016/j.biomaterials.2019.119749
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发表时间：
2020-02-01
期刊：
影响因子：
14
通讯作者：
Tang, Ben Zhong
中科院分区：
文献类型：
--
作者：
Li, Youmei;Wu, Qian;Tang, Ben Zhong
具有聚集诱导发射(AIE)特性的光敏剂在包括荧光成像和光动力学治疗(PDT)在内的癌症治疗中引起了极大的兴趣。然而，在光动力疗法的临床试验中，开发突出的药物输送系统以提高AIE光敏剂的光动力疗法效率是非常可取的，但仍是一项具有挑战性的任务。本文设计并实现了一种基于刺激响应型纳米胶束作为AIE光敏剂的特殊载体的增强光动力学效应的新策略，即MeTTMN。这些具有刺激响应性的纳米胶束负载MeTTMN具有良好的生物相容性、优异的稳定性、合适的纳米粒子尺寸、较高的负载效率、突出的成像质量和显著提高的光动力学性能，最终使它们显著地令人印象深刻，显著优于商用的MeTTMN纳米胶束。因此，这项研究为荧光成像引导的光动力疗法提供了一个理想的模板，也为临床试验提供了一个有前途的候选者。
Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficiency of AIE photosensitizers is highly desirable but still remain a challenging task. Herein, a novel strategy is designed and performed for boosting PDT effect based on stimuli-responsive nano-micelles as extraordinary carriers for an AIE photosensitizer, namely MeTTMN. Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle size, high loading efficiency, outstanding imaging quality and significantly promoted PDT performance, eventually making them remarkably impressive and significantly superior to commercially available nano-micelles carried MeTTMN. This study thus offers an ideal template for fluorescence imaging-guided PDT, as well as a promising candidate for clinical trials.