The Role of Socioregional Factors in Moderating Genetic Influences on Early Adolescent Behavior Problems and Alcohol Use
The Role of Socioregional Factors in Moderating Genetic Influences on Early Adolescent Behavior Problems and Alcohol Use
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DOI：
10.1111/j.1530-0277.2009.01011.x
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Rose, Richard J.
中科院分区：
文献类型：
--
作者：
Dick, Danielle M.;Bernard, Matthew;Rose, Richard J.
背景：双胞胎和家庭研究表明，青少年饮酒和行为问题受到遗传和环境因素的影响。最近，研究已经开始调查遗传和环境的影响如何相互作用，并正在努力确定特定的环境变量，调节遗传易感性的表达。以前，我们已经报道，社区层面的因素，包括城市/农村居住，移民率，年轻人的患病率，适度的遗传效应对酒精使用的重要性，在青春期后期（16至18岁）。在这里，我们将这些发现扩展到测试这些社会区域因素对酒精使用和行为问题的调节作用，在一个年轻的青少年芬兰双胞胎样本中进行评估。方法：使用来自基于人口的芬兰双胞胎研究FinnTwin 12的数据，将生物计量双胞胎模型拟合到> 1,400对双胞胎的数据，以检查每个社会区域调节变量对14岁时测量的酒精使用和12岁时测量的行为问题的重要性。然而，遗传因素对行为问题的影响明显缓和，其影响仅限于女孩。遗传的影响承担更大的重要性，在城市环境中，社区更大的迁移，社区有较高的比例稍年长的adolescents.Conclusions：观察到的适度影响在青春期早期的行为问题，酒精使用的影响，发现在青春期后期在一个独立的样本，提供进一步支持的想法，行为问题可能代表了早期表现的倾向，随后的酒精问题。我们的研究结果也支持越来越多的证据表明，女性可能比男性更容易受到各种环境影响。
Background:Twin and family studies have demonstrated that adolescent alcohol use and behavior problems are influenced by a combination of genetic and environmental factors. More recently, studies have begun to investigate how genetic and environmental influences may interact, with efforts underway to identify specific environmental variables that moderate the expression of genetic predispositions. Previously, we have reported that community-level factors, including urban/rural residency, migration rates, and prevalence of young adults, moderate the importance of genetic effects on alcohol use in late adolescence (ages 16 to 18). Here, we extend these findings to test for moderating effects of these socioregional factors on alcohol use and behavior problems assessed in a younger sample of adolescent Finnish twins.Methods:Using data from the population-based Finnish twin study, FinnTwin12, biometric twin models were fit to data on > 1,400 twin pairs to examine the significance of each of the socioregional moderating variables on alcohol use measured at age 14, and behavior problems, measured at age 12.Results:We find no evidence of a moderating role of these socioregional variables on alcohol use; however, there was significant moderation of genetic influences on behavior problems, with effects limited to girls. Genetic influences assumed greater importance in urban settings, communities with greater migration, and communities with a higher percentage of slightly older adolescents.Conclusions:The moderation effects observed on behavior problems in early adolescence paralleled the effects found on alcohol use late in adolescence in an independent sample, providing further support for the idea that behavior problems may represent an earlier manifestation of the predisposition to subsequent alcohol problems. Our findings also support the growing body of evidence suggesting that females may be more susceptible to a variety of environmental influences than males.