Consumption of two whole kiwifruit (Actinide chinensis) per day improves lipid homeostasis, fatty acid metabolism and gut microbiota in healthy rats
Consumption of two whole kiwifruit (Actinide chinensis) per day improves lipid homeostasis, fatty acid metabolism and gut microbiota in healthy rats
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每天食用两个完整的猕猴桃（Actinide chinensis）可改善健康大鼠的脂质稳态、脂肪酸代谢和肠道微生物群
DOI：
10.1016/j.ijbiomac.2020.04.028
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发表时间：
2020-08-01
影响因子：
8.2
通讯作者：
Yang, Xingbin
中科院分区：
文献类型：
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作者：
Alim, Aamina;Li, Ting;Yang, Xingbin
研究了两种猕猴桃果肉（ACF）和两种猕猴桃果皮果肉（ACFP）对脂质稳态的影响。在健康大鼠中研究脂肪酸代谢和肠道微生物群。ACF和ACFP干预4周可显著降低大鼠的总胆固醇、总甘油三酯，并升高高密度脂蛋白水平。ACF和ACFP通过降低肝组织MDA含量、提高GSH-Px和SOD活性，减轻脂质过氧化损伤。ACFP还能显著降低大鼠血清中饱和脂肪酸的含量，增加肝脏和脂肪组织中多不饱和脂肪酸的含量。肠道菌群分析表明，ACE和ACFP明显增加了肠道菌群的微生物丰富度和多样性。厚壁菌门/拟杆菌门比值从ND组的3.04显著降低到ACF组的1.34和ACFP组的2.12。此外，ACF和ACFP显着增加了有益菌（乳杆菌属和Barnesiella）的丰度，减少了有害菌（肠球菌属，埃希氏菌属和葡萄球菌属）。总体而言，ACFP比ACF发挥更有效的健康改善作用。本研究为开发具有显著保健功效的猕猴桃（含果皮）新型天然产物提供了科学依据。(C)2020爱思唯尔B. V.保留所有权利。
Golden kiwifruit (Actinidia chinensis) peel is a by-product enriched with polyphenols.The effects of fleshes of two Actinidia chinensis fruits (ACF) and fleshes with peels of two Actinidia chinensis fruits (ACFP) on lipid homeostasis. fatty acid metabolism and gut microbiota was investigated in healthy rats. Intervention of ACF and ACFP for 4 weeks significantly reduced total cholesterol, total triglycerides, and increased the high-density lipoprotein levels in rats. ACF and ACFP ameliorated lipid peroxidation in rats, by the lowering hepatic MDA level and enhancing GSH-Px and SOD activities. In addition, ACFP significantly decreased the saturated fatty acids in serum and increased the polyunsaturated fatty adds in hepatic and scrum of rats. Analysis of gut microbiota revealed that ACE and ACFP evidently increased the microbial richness and diversity of gut microbiota. The Firmicutes/Bacteroidetes ratio was significantly reduced from 3.04 in ND group to 1.34 and 2.12 in ACF and ACFP groups, respectively. Moreover, ACF and ACFP significantly increased the abundance of beneficial bacteria (Lactobacillus and Barnesiella) and reduced harmful bacteria (Entemcoccus, Escherichia, and Staphylococcus). Overall, ACFP exerts more potent health-improving effects than ACF. Our study provides a scientific basis for the development of kiwifruit (including pericarp)-based novel natural products with significant health benefits. (C) 2020 Elsevier B.V. All rights reserved.