Two new styryl lactones, 9-deoxygoniopypyrone and 7-epi-goniofufurone, from Goniothalamus giganteus.
Two new styryl lactones, 9-deoxygoniopypyrone and 7-epi-goniofufurone, from Goniothalamus giganteus.
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DOI：
10.1021/np50076a017
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发表时间：
1991-07
影响因子：
5.1
通讯作者：
X. Fang;Jon E. Anderson;Ching-Jer Chang;J. McLaughlin;Phillip E. Fanwick
中科院分区：
文献类型：
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作者：
X. Fang;Jon E. Anderson;Ching-Jer Chang;J. McLaughlin;Phillip E. Fanwick
从哥纳香（Goniothalamus）茎皮中分离得到两个新的苯乙烯基内酯化合物：9-deoxygoniopyrone [1]和7-epi-goniofurone [3]，以及一个已知的苯乙烯基内酯化合物goniodiol [5]。通过IR、MS、1H-NMR、13 C-NMR和1H-1H COSY光谱确定了结构，并通过X射线晶体学分析确定了相对构型。与goniopyrone [2]和goniofurone [4]不同，新的苯乙烯基内酯1和3对人肿瘤细胞均未显示出显著的生物活性。然而，戈碘醇[5]对人肺肿瘤细胞（A-549）显示出显著的选择性细胞毒性。
Two new styryl lactones, 9-deoxygoniopypyrone [1] and 7-epi-goniofufurone [3], and a known styryl lactone, goniodiol [5], were isolated from the stem bark of Goniothalamus giganteus. The structures were elucidated by ir, ms, 1H-nmr, 13C-nmr, and 1H-1H COSY spectra; the relative configurations were determined by X-ray crystallographic analysis. Unlike goniopypyrone [2] and goniofufurone [4], neither of the new styryl lactones 1 and 3 showed significant bioactivities to human tumor cells. However, goniodiol [5] showed significant and selective cytotoxicity against human lung tumor cells (A-549).