A PHARMACOLOGICAL ANALYSIS OF PERISTALTIC REFLEX IN ISOLATED COLON OF GUINEA-PIG OR CAT
A PHARMACOLOGICAL ANALYSIS OF PERISTALTIC REFLEX IN ISOLATED COLON OF GUINEA-PIG OR CAT
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DOI：
10.1111/j.1476-5381.1970.tb12897.x
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发表时间：
1970-01-01
影响因子：
7.3
通讯作者：
LECCHINI, S
中科院分区：
文献类型：
--
作者：
CREMA, A;FRIGO, GM;LECCHINI, S
1.结肠的蠕动反射是由局部的腔内刺激引起的。纵向被毛的收缩反应，包括两个阶段，在推进开始之前开始。虽然纵肌和环肌的收缩通常是相关的，但它们也可以是相互独立的。特别是，纵向收缩似乎不是推进所必需的。2.无论是纵向反射收缩和环肌扩张的节段性反应，即收缩以上和以下的团的放松，被废除的河豚毒素和神经节阻滞剂。3.在豚鼠中，纵向和环形反射收缩通常对抗毒蕈碱、抗组胺药和抗色胺药有抵抗力，但在猫中，它们被抗毒蕈碱药消除。然而，在这两个物种中，阿托品和东莨菪碱可以通过选择性地阻断下行抑制来损害推进。在猫中，有可能找到消除下行抑制而不影响纵向和环形肌肉收缩反应的剂量。4.去交感神经和利血平预处理不影响推进活动。去神经器官中下行抑制的维持表明环形肌肉的抑制神经元不是肾上腺素能的。5.在药物作用的基础上，探讨了影响推进极性的可能神经机制。这样的机制似乎需要一个抑制途径，在某些时候涉及毒蕈碱受体。6.盆腔神经刺激促进推进活动。在低频率和高频率刺激下，透壁刺激的效果是不同的。交感神经刺激对反射反应的抑制作用似乎主要是由于对内在神经结构的作用。
1. The peristaltic reflex in the colon was elicited by a localized intraluminal stimulus. The contractile response of the longitudinal coat, which consists of two phases, begins before the start of propulsion. Although the contractions of the longitudinal and circular musculature are usually associated, they may be independent of each other. In particular, the longitudinal contraction does not seem to be necessary for propulsion. 2. Both the longitudinal reflex contraction and the segmental responses of the circular muscle to distension, namely a contraction above and a relaxation below the bolus, are abolished by tetrodotoxin and ganglion blocking agents. 3. In the guinea-pig, longitudinal and circular reflex contractions are usually resistant to antimuscarine, antihistamine and antitryptamine drugs but in the cat they are abolished by antimuscarine drugs. In both species, however, atropine and hyoscine can impair propulsion by blocking selectively the descending inhibition. In the cat, it is possible to find doses which abolish the descending inhibition without affecting the contractile responses of the longitudinal and circular muscle. 4. Sympathetic denervation and pretreatment with reserpine do not affect the propulsive activity. The maintenance of the descending inhibition in denervated organs suggests that the inhibitory neurones to the circular muscle are not adrenergic. 5. On the basis of the effects of drugs, the possible nervous mechanism subserving the polarity of propulsion has been examined. Such a mechanism seems to require an inhibitory pathway involving muscarinic receptors at some point. 6. Pelvic nerve stimulation facilitates propulsive activity. The effect of transmural stimulation is different at low and at high frequencies of stimulation. The inhibitory effect of sympathetic stimulation on the reflex responses seems to be due mainly to an action on intrinsic nervous structures.