Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants.
Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants.
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DOI：
10.1016/j.biomaterials.2016.01.016
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发表时间：
2016-04
期刊：
影响因子：
14
通讯作者：
Heilshorn SC
中科院分区：
文献类型：
--
作者：
Raphel J;Holodniy M;Goodman SB;Heilshorn SC
关节置换术假体失败的两个主要原因是无菌性松动和假体周围关节感染。随着初次和翻修关节置换手术数量的增加，缓解这些失效模式的策略变得越来越重要。该领域最近的大部分工作都集中在涂层的设计上，以防止感染而忽略骨矿化，反之亦然，以促进骨整合而忽略微生物敏感性。然而，这两种涂层功能都需要实现植入物的长期成功;因此，在开发新的骨科涂层策略期间，必须同时评价这两种模式。在这篇综述中，我们讨论了多功能骨科涂层的设计，可以抑制微生物细胞，同时仍然促进骨整合的最新进展和未来的方向。
The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration.