LONG-TERM OUTCOME OF PRIMARY NEPHROTIC SYNDROME
LONG-TERM OUTCOME OF PRIMARY NEPHROTIC SYNDROME
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DOI：
10.1136/adc.57.7.544
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发表时间：
1982-01-01
影响因子：
5.2
通讯作者：
HALLMAN, N
中科院分区：
文献类型：
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作者：
KOSKIMIES, O;VILSKA, J;HALLMAN, N
对114例原发性肾病综合征患儿进行了5-14年的前瞻性随访。94例患儿的尿样在泼尼松治疗的最初8周内变为无蛋白，这些患儿的结局良好：其中74例至少3年无症状，18例在最后3年复发，只有1例患儿仍有蛋白尿。所有这些孩子都有正常的肾功能和血压。一名儿童意外死亡。儿童（20）没有回应的初步强的松治疗，其中13人缓解后，其中2人在过去3年复发。7例对强的松完全耐药，其中4例死于肾功能衰竭，其余3例有持续性蛋白尿，肌酐水平正常; 1例有高血压。在初始治疗期间缓解表明预后良好，但2/3的初始无应答者也表现良好。
Children (114) with primary nephrotic syndrome were followed up prospectively for periods of 5-14 yr. Urine samples from 94 became protein-free during the initial 8 wk course of prednisone, and the outcome for these children was good: 74 of them were free of symptoms for at least 3 yr, 18 had relapses during the last 3 yr, and only 1 child still has proteinuria. All these children have normal renal function and blood pressure. One child died accidentally. Children (20) did not respond to the initial prednisone treatment; of them, 13 had remissions later, of whom 2 have had relapses during the last 3 yr. Seven were totally resistant to prednisone 4 of whom died in renal failure, the remaining 3 have persistent proteinuria with normal levels of creatinine; 1 has high blood pressure too. Remission during the initial treatment indicated a good prognosis, but 2/3 of the initial nonresponders also fared well.