Neuroimmune mechanisms underlying Alzheimer’s disease: Insights into central and peripheral immune cell crosstalk
Neuroimmune mechanisms underlying Alzheimer’s disease: Insights into central and peripheral immune cell crosstalk
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DOI：
10.1016/j.arr.2022.101831
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发表时间：
2022-12
影响因子：
13.1
通讯作者：
Yuqing Liu;Yejun Tan;Zheyu Zhang;Hongli Li;Min Yi;Zhen Zhang;Shan Hui;Weijun Peng
中科院分区：
文献类型：
--
作者：
Yuqing Liu;Yejun Tan;Zheyu Zhang;Hongli Li;Min Yi;Zhen Zhang;Shan Hui;Weijun Peng
阿尔茨海默病(AD)是一种高度威胁生命的神经退行性疾病。免疫系统调节失调在阿尔茨海默病的发病中起着至关重要的作用，近年来引起了广泛关注。中枢和外周免疫反应参与了AD的发病机制。免疫变化先于Aβ相关的老年斑形成和tau相关的神经原纤维缠结，这是公认的AD的病理特征。因此，阐明阿尔茨海默病发生发展的免疫相关机制有助于从源头上预防和治疗阿尔茨海默病，在病变发生之前阻断其进展。为了了解AD的具体发病机制，研究中枢和外周免疫在AD中的作用非常重要。本文综述了AD发病的免疫相关机制，重点介绍了各种中枢和外周免疫细胞的作用，并描述了AD发病过程中中枢和外周免疫之间可能存在的串扰。这一综述为AD的治疗提供了新的见解，并为未来AD的免疫相关研究提供了新的方向。
Alzheimer’s disease (AD) is a highly life-threatening neurodegenerative disease. Dysregulation of the immune system plays a critical role in promoting AD, which has attracted extensive attention recently. Central and peripheral immune responses are involved in the pathogenesis of AD. Immune changes precede Aβ-associated senile plaque formation and tau-related neurofibrillary tangles, which are the recognised pathological features of AD. Therefore, elucidating immune-related mechanisms underlying the development of AD can help to prevent and treat AD at the source by blocking its progression before the development of pathological changes. To understand the specific pathogenesis of AD, it is important to examine the role of central and peripheral immunity in AD. This review summarises immune-related mechanisms underlying the pathogenesis of AD, focusing on the effect of various central and peripheral immune cells, and describes the possible crosstalk between central and peripheral immunity during the development of AD. This review provides novel insights into the treatment of AD and offers a new direction for immune-related research on AD in the future.