Preprandial Single Oral Dose of Sitagliptin Does Not Affect Circulating Ghrelin and Gastrin Levels in Normal Subjects
Preprandial Single Oral Dose of Sitagliptin Does Not Affect Circulating Ghrelin and Gastrin Levels in Normal Subjects
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DOI：
10.1159/000280583
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发表时间：
2010-01-01
期刊：
影响因子：
3.1
通讯作者：
Weng, Shuen-Fu
中科院分区：
文献类型：
--
作者：
Huang, Chen-Ling;Hsu, Chung-Huei;Weng, Shuen-Fu
目的：确定口服西格列汀对生长素释放肽和胃泌素激素分泌的影响。方法：本研究招募了 10 名健康志愿者。在口服 100 毫克西他列汀片剂之前抽取基线血样。给药后0.5和1小时获得两份血样。在 0.5、1 和 2 小时另外抽取 3 份餐后血样。放射免疫测定法用于测定激素水平。使用学生 t 检验、皮尔逊相关分析和重复测量方差分析的多变量方法进行统计。结果：服用西格列汀后，餐前，循环胃饥饿素、胃泌素、胰岛素和葡萄糖水平没有显着变化。仅在进餐后，生长素释放肽水平才会逐渐持续下降，直至研究结束，而胃泌素、胰岛素和葡萄糖水平在 0.5 小时内观察到快速且暂时的上升。随后胃泌素、胰岛素和葡萄糖的水平逐渐下降。结论：餐前口服西格列汀剂量不影响正常受试者的循环胃饥饿素、胃泌素、胰岛素和葡萄糖浓度。仅在进餐后，胃饥饿素和胰岛素水平才会下降，而胃泌素和胰岛素水平则会上升。这些结果支持这样的理论：西他列汀可能不会导致食欲增强的体重增加和胰岛素引起的低血糖。版权所有 (C) 2010 S. Karger AG，巴塞尔
Aims: To determine the effect of an oral dose of sitagliptin on the secretion of ghrelin and gastrin hormones. Methods: Ten healthy volunteers were recruited in this study. A baseline blood sample was drawn before oral dosing with a 100mg tablet of sitagliptin. Two blood samples were obtained 0.5 and 1 h after dosing. Three additional postprandial blood samples were drawn at 0.5, 1, and 2 h. Radioimmunoassay was used for determining hormonal levels. A Student's t test, Pearson correlation analysis, and multivariate approach to repeated-measures analysis of variance were used for statistics. Results: After sitagliptin dosing, but before the meal, there was no significant change in circulating ghrelin, gastrin, insulin, and glucose levels. Only after meal loading was there a progressive and persistent decline in ghrelin levels until the end of the study, while a rapid and temporary rise in gastrin, insulin, and glucose levels at 0.5 h was observed. The levels of gastrin, insulin, and glucose then declined progressively. Conclusions: Preprandial oral dose of sitagliptin does not affect circulating ghrelin, gastrin, insulin, and glucose concentrations in normal subjects. Decreased ghrelin and increased gastrin and insulin levels occurred only after meal loading. These results support the theory that sitagliptin might not cause appetite-enhanced body weight gain and insulin-induced hypoglycemia. Copyright (C) 2010 S. Karger AG, Basel