MOLECULAR-GENETICS OF HUMAN COLOR-VISION - THE GENES ENCODING BLUE, GREEN, AND RED PIGMENTS
MOLECULAR-GENETICS OF HUMAN COLOR-VISION - THE GENES ENCODING BLUE, GREEN, AND RED PIGMENTS
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DOI：
10.1126/science.2937147
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发表时间：
1986-04-11
期刊：
影响因子：
56.9
通讯作者：
HOGNESS, DS
中科院分区：
文献类型：
--
作者：
NATHANS, J;THOMAS, D;HOGNESS, DS
人类的色觉是基于三种感光色素。对编码这三种色素载脂蛋白的基因组和互补DNA克隆进行了分离和测序。所得氨基酸序列与视紫红质同源性为41%±1%。红色和绿色颜料显示出96%的同一性，但与蓝色颜料的同一性只有43%。绿色色素基因在颜色正常的个体中数量不同，并且与单个红色色素基因一起，被认为位于X染色体内的首尾串联阵列中。
Human color vision is based on three light-sensitive pigments. The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described. The deduced amino acid sequences show 41 ± 1 percent identity with rhodopsin. The red and green pigments show 96 percent mutual identity but only 43 percent identity with the blue pigment. Green pigment genes vary in number among color-normal individuals and, together with a single red pigment gene, are proposed to reside in a head-to-tail tandem array within the X chromosome.